STAGES OF LYMPHOCYTE DEVELOPMENT (T-CELLS)

Question 1

T cells comprises _____ of the circulating lymphocyte population

Answer 1

60-80%

Question 2

The thymocytes enter the _______ from the ____ and travels within ____, mediated by _____ and takes up to _____?

Answer 2

Thymus
cortex
medulla
cytokines
3 weeks

Question 3

How many percent of T cells die within the thymus?

Answer 3

~97%

Question 4

This stage lacks CD4 and CD8

Answer 4

Double Negatuve stage

Question 5

Under DNS, where does the thymocytes enter?

Answer 5

Cortex

Question 6

This cells migrate to other parts pf the body

Answer 6

Gamma-delta DN

Question 7

This cells is incapable of producing T-cell receptors

Answer 7

Gamma-delta DN

Question 8

This stage has the presence of CD4+ and CD8+

Answer 8

Double positive stage

Question 9

The cells of the thymus will check if T-cells can recognize foreign antigen from self-antigen in association with Class I and II MHC molecules

Answer 9

Positive selection

Question 10

T cells must not cells that have cells that destroys MCH molecules

Answer 10

MHC restriction

Question 11

Where does the DPS happens?

Answer 11

Corticomedullary regions

Question 11

Elimination of thymocytes that produce strong reactions against self-antigens

Answer 11

Negative selection

Question 11

Mature T-cells are also naive T-cells. True or False?

Answer 11

True

Question 11

How long do mature t-cells stay within the thymus?

Answer 11

12 days

Question 12

This is the most prominent among the different helper T-cells subsets

Answer 12

Th1 and 2

Question 12

This increases inflammation and joint destruction and autoimmune diseases

Answer 12

Th17

Question 13

The main purpose of this is to provide cytokines that are necessary for the activity of other immune cells

Answer 13

Helper T-cells

Question 14

Presentation of Ag with Class II MHC

Answer 14

Helper T cells

Question 15

This has more direct interaction with cells within the body

Answer 15

Cytotoxic t-cells

Question 16

This will be released into the cytoplasm of the targeted cells.

Answer 16

Granzymes

Question 16

Presentation of intracellular pathogens or tumor cells with Class I MHC in lymph nodes

Answer 16

Cytotoxic t-cells

Question 17

These are necessary for the functionality of the cytotoxic T-cell

Answer 17

Granzymes
Perforins

Question 17

This will be released from the granules or vesicles of the cytotoxic T-cells

Answer 17

Perforfin

Question 17

Where would be perforfin released to?

Answer 17

Granules or vesicles of the cytotoxic T-cells

Question 17

Where would be the granzyme released to?

Answer 17

Cytoplasm

Question 18

How would granzyme destroy the cells?

Answer 18

Activate nuclease enzyme and facilitate mitochondrial destruction