CLINICAL SIGNIFICANCE OF THE COMPLEMENT

Question 1

A continuous, uncontrolled activation of the
complement cascade can lead to?

Answer 1

Tissue damage
Tissue death

Question 2

▪
Large quantities of C3a and C5a that
would be generated → Neutrophil
aggregation
▪
Can also lead to blood clotting

Answer 2

Systemic activation due to gram-negative
septicemia

Question 3

Antibody that targets to
blood cell antigens

Answer 3

Cold autoimmune hemolytic anemia

Question 4

Lupuslike syndrome; recurrent infection

Answer 4

C1 (q, r, or s)

Question 5

Lupuslike syndrome; recurrent infection;
atherosclerosis

Answer 5

C2

Question 6

Severe recurrent infection;
glomerulonephritis

Answer 6

C3

Question 7

Lupuslike syndrome

Answer 7

C4

Question 8

Neisseria Infection

Answer 8

C5 - C8; Properdin

Question 9

No known disease association

Answer 9

C9

Question 10

Hereditary angioedema

Answer 10

C1-INH

Question 11

Paroxysmal nocturnal hemoglobinuria

Answer 11

DAF & MIRL

Question 12

Recurrent pyogenic infection

Answer 12

Factor H or
Factor I

Question 13

Pneumococcal diseases, sepsis,
Neisseria infection

Answer 13

MBL

Question 14

Pneumococcal diseases

Answer 14

MASP-2

Question 15

Most common deficiency?

Answer 15

C2 deficiency

Question 16

Most serious or severe deficiency

Answer 16

C3 deficiency