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Immunoserology > ANTIGEN > Flashcards

ANTIGEN Flashcards

1
Q

Macromolecules that is capable triggering an adaptive
immune response by inducing formation of antibodies or
sensitized T- cells of an immunocompetent host

A

Immunogen

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2
Q

Can evoke an immune response

A

Immunigen

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3
Q

• Substance that reacts with antibody or sensitized T cells but
may not evoke an immune response
• Can only bind sensitized T cells or antibody, not capable of sensitizing T and B cells (no reaction)

A

Antigen

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4
Q

Ability to induce a humoral and/or cell-mediated immune
response

A

Immunoginecity

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5
Q

Ability to combine specifically with the final products of the
immune response

A

Antigenicity

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6
Q

What are the final products of antigenicity?

A

secreted antibodies and/or surface
receptors on T-cell

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7
Q

What are the factors influencing the immune response?

A

Size
Foreignness
Chemical composition and molecular complexity
Adjuvants
Route, Dose, Timing

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8
Q

This is the ability of the person to mount an immune response

A

Immunocompetent

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9
Q

Coupled with a certain receptor

A

Antigenicity

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10
Q

their immune system is not completely developed

A

Neonates

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11
Q

Pediatricians monitor closely neonates that get sick from ___________ old

A

0-3
months

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12
Q

the immune system won’t work well if the body
does not receive the enough nutrition that it needs (especially
here in the Philippines and children

A

Malnutrition

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13
Q

What are the routes of inoculation?

A

Intravenous
Intradermal
Subcutaneous
Oral contact

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14
Q

This is inoculated into the vein.The fastest route of entry of an immunogen because it will
enter directly into the bloodstream

A

Intravenous

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15
Q

This is inoculated into the skin.

A

Intradermal

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16
Q

This is inoculated beneath the skin / tissue.

A

Subcutaneous

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17
Q

What is the primary organ to fight off the immunogen in an intravenous route?

A

Spleen

18
Q

What is the example of subcutaneous?

A

Local lymph nodes

19
Q

Linked to MHC (Major Histocompatibility Complex) and to
receptors generated during T and B lymphocyte development

A

Genetic capacity

20
Q

system of genes that code for cell surface molecules that
play an important role in antigen recognition

A

MHC (Major Histocompatibility Complex)

21
Q

What is the MW of the best immunogens?

A

100,000 Daltons

22
Q

This route of inoculation has a stronger stimuli than subcutaneous.

A

Intradermal

23
Q

What is the rule of thumb of macromolecular size?

A

the greater the molecular weight, the more
potent the molecule to induce an immune response

24
Q

Lymphocyte capable of reacting with self- antigen is normally eliminated. Will determine if the antigen foreign or self
. Should be eliminated because it is a self-antigen

A

Foreignness

25
Q

Which are the best immunogens?

A

Proteins

26
Q

Which is the 2nd best immunogen?

A

Polysaccharides

27
Q

This is the least immunogenic and must be attached to a carrier particle before being an
immunogen.

A

Lipid and nucleic acids

28
Q

These are antigenic determinants and are molecular shapes or configurations that are
recognized by B or T cells

A

Epitopes

29
Q

Immunologically active regions of an immunogen that bind to
antigen-specific membrane receptors on lymphocytes or to
secreted antibodies

A

Epitopes

30
Q

amino acids following one another on a single chain

A

SEQUENTIAL OR LINEAR EPITOPES

31
Q

results from the folding of one chain or multiple chains,
bringing certain amino acids from different segments of a
linear sequence or sequences into close proximity with each
other so they can be recognized together

A

CONFORMATIONAL OR DISCONTINUOUS EPITOPE

32
Q

Small organic compound that are antigenic but not
immunogenic

A

Haptens

33
Q

reactions that we
observe in the serology laboratory indicating an
antigen-antibody reaction

A

Precipitation/ agglutination

34
Q

What should a hapten do to become a complete antigen/immunogen?

A

they should be
coupled to a carrier

35
Q

Who wrote the specificity of the serological reaction?

A

Karl Landsteiner

36
Q

He discovered that antibodies not only recognize chemical
features such as polarity, hydrophobicity, and ionic charge,
but the overall three-dimensional configuration is also
important. Immunized rabbits with haptens attached to a carrier
molecule.

A

Karl Landsteiner

37
Q

• Substances that are administered with an immunogen that
increase the immune response in order to provide immunity
to a particular disease
• Used to make vaccine

A

Adjuvants

38
Q

This is an example of Adjuvants used to complex with the
immunogen to increase its size and to prevent a rapid escape
from the tissues

A

Aluminum salts

39
Q

• Antigens that belong to the host
• Do not evoke an immune response under normal
circumstances
• The only problem that will occur is that if the lymphocytes
don’t have the capability of discriminating self from non-self

A

Autoantigens

40
Q

• From other members of the host’s species
• Human to human
• Capable of eliciting an immune response

A

Alloantigens

41
Q

From other species such as other animals, plants or
microorganisms

A

Heteroantigens

42
Q

• hetereoantigens that exist in unrelated plants or animals
• Either identical or closely related in structure so that
antibody to one will cross- react with antigen of the other

A

Heterophile antigens

Immunoserology (21 decks)

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