STAGES OF LYMPHOCYTE DEVELOPMENT (B-CELLS)

Question 1

What are the stages of B cells maturation?

Answer 1

Pro-B cells
Pre-B cell
Immature B cells
Mature B cells
Plasma cells
Memory cells

Question 2

Where is the Pro-B cells found?

Answer 2

BM stromal cells

Question 3

This cells will help the grow of B cells

Answer 3

Stromal cells

Question 4

This is a stage of B cell maturation where it is Antigen-Independent Phase

Answer 4

Pro-B cell

Question 5

What are the distinctive markers of Pro-B cells?

Answer 5

c-Kit, CD19, CD45R, CD43, CD24

Question 6

What are the intracellular proteins of Pro-B cells?

Answer 6

Tdt, RAG-1 and RAG-2

Question 7

This is marked by the production of heavy chains and surrogate light chains.

Answer 7

Pre-B cells

Question 8

What are the surface markers of Pre-B cells?

Answer 8

CD19, CD24 and CD45R

Question 9

The presence of IgM on cell surface is the distinct characteristics of this phase.

Answer 9

Immature B cell

Question 10

Under Immature B cells, the cell must be tolerant to?

Answer 10

Self antigens (central tolerance)

Question 11

The bone marrow will check if the B cells are capable of destroying autoantigens and subsequently producing antibody against own antigen

Answer 11

Central tolerance

Question 12

This phase is denoted by the presence of IgD monomer on its cell surface.

Answer 12

Mature B cells

Question 13

This represents the most fully differentiated lymphocyte

Answer 13

Plasma cell

Question 14

The Ab pxn of plasma cells is found where?

Answer 14

Germinal layer zone in 2 lymphoid organs or in the B,

Question 15

This safeguard our immune system

Answer 15

Memory cells

Question 16

Where is memory cells founf?

Answer 16

Germinal layer