RECEPTORS ON CELL MEMBRANE FOR COMPLEMENT COMPONENTS

Question 1

Cofactor for Factor I; mediates transport
of immune complexes

Answer 1

CR1 (CD 35)

Question 2

B- cell co-receptor for antigen with
CD19

Answer 2

CR2 (CD 21)

Question 3

Adhesion and increased activity of
phagocytic cells

Answer 3

CR3 (CD11b / CD 18)
&
CR4 (CD11c / CD 18)

Question 4

Dissociates C2b or Bb from binding
sites, thus preventing formation of C3
convertase

Answer 4

Decay-accelerating factor

Question 5

Prevents insertion of C9 into cell
membrane

Answer 5

Membrane - Inhibitor of Reactive Lysis

Question 6

Cofactor for Factor I cleavage of C3b
and C4b

Answer 6

MCP (CD 46)

Question 7

What is MW of CD 35?

Answer 7

165,000 - 280,000

Question 8

What is MW of CD 46?

Answer 8

50,000 - 70,000

Question 9

What is MW of CD 55?

Answer 9

70,000

Question 10

it binds C3b and C4b but has the greatest
affinity for C3b

Answer 10

CD 35

Question 11

It is the most efficient cofactor for factor
I - mediated cleavage of C3b

Answer 11

Membrane cofactor protein (MCP)

Question 12

It is capable of dissociating both classical and
alternative pathway C3 convertase

Answer 12

CD 55 (DAF)

Question 13

Found on virtually all epithelial and
endothelial cells except erythrocytes.

Answer 13

MCP (CD46)