PROTEINS OF COMPLEMENT SYSTEM Flashcards
Binds to Fc region of IgM and IgG
C1q
Activates C1s
C1r
Under classical pathway which serum protein Cleaves C4 and C2?
C1s
Part of C3 convertase (C4b)
C4
Binds to C4b—forms C3 convertase
C2
Key intermediate in all pathways
C3
Initiates membrane attack complex
C5
Binds to C5b in MAC
C6
Binds to C5bC6 in MAC
C7
Starts pore formation on membrane
C8
Polymerizes to cause cell lysis
C9
Among the serum proteins of the complement system under classical pathway, which among them has the highest molecular weight?
C1q
Among the serum proteins of the complement system under classical pathway, which among them has the lowest molecular weight?
C9
Among the serum proteins of the complement system under the classical pathway, which among them has the highest concentration?
C3
Among the serum proteins of the complement system under the classical pathway, which among them has the lowest concentration?
C2