PROTEINS OF COMPLEMENT SYSTEM Flashcards

1
Q

Binds to Fc region of IgM and IgG

A

C1q

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2
Q

Activates C1s

A

C1r

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3
Q

Under classical pathway which serum protein Cleaves C4 and C2?

A

C1s

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4
Q

Part of C3 convertase (C4b)

A

C4

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5
Q

Binds to C4b—forms C3 convertase

A

C2

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6
Q

Key intermediate in all pathways

A

C3

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7
Q

Initiates membrane attack complex

A

C5

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8
Q

Binds to C5b in MAC

A

C6

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9
Q

Binds to C5bC6 in MAC

A

C7

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10
Q

Starts pore formation on membrane

A

C8

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11
Q

Polymerizes to cause cell lysis

A

C9

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12
Q

Among the serum proteins of the complement system under classical pathway, which among them has the highest molecular weight?

A

C1q

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13
Q

Among the serum proteins of the complement system under classical pathway, which among them has the lowest molecular weight?

A

C9

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14
Q

Among the serum proteins of the complement system under the classical pathway, which among them has the highest concentration?

A

C3

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15
Q

Among the serum proteins of the complement system under the classical pathway, which among them has the lowest concentration?

A

C2

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16
Q

Binds to C3b to form C3 convertase

A

Factor B

17
Q

Cleaves factor B

A

Factor D

18
Q

Stabilizes C3bBb–C3 convertase

A

Properdin

19
Q

Among the serum proteins of the complement system under alternative pathway, which among them has the highest molecular weight?

A

Factor B

20
Q

Among the serum proteins of the complement system under alternative pathway, which among them has the lowest molecular weight?

A

Factor D

21
Q

Among the serum proteins of the complement system under alternative pathway, which among them has the highest concentration?

A

Factor B

22
Q

Among the serum proteins of the complement system under alternative pathway, which among them has the lowest concentration?

A

Factor D

23
Q

Binds to mannose

A

MBL

24
Q

The function of this serum protein is unknown

A

MASP-1

25
Q

Cleaves C4 and C2

A

MASP-2