spironolactone Flashcards
1
Q
Mechanism of action
A
aldosterone antagonist
2
Q
Where in the renal tubule does it act?
A
Cortical collecting duct
3
Q
Indications for spironolactone
A
ascites (large doses, 100-200mg)
hypertension: ‘step 4’
heart failure
nephrotic syndrome
Conn’s syndrome
4
Q
Common side effects of aldosterone antagonists
A
hyperkalaemia
gynaecomastia: less common with eplerenone
5
Q
Addition of low dose spironolactone reduces all cause mortality in heart failure. TRUE/FALSE?
A
TRUE
6
Q
A
