Nephrotic syndrome Flashcards
1
Q
Triad
A
- Proteinuria
- Hypoalbuminaemia
- Oedema
2
Q
Why do patients with nephrotic syndrome have a predisposition to thrombosis?
A
Loss of antithrombin-III and proteins C and S
associated rise in fibrinogen
3
Q
Which of the glomerulonephritides can present with nephrotic syndrome?
A
- minimal change GN
- membranous GN
- focal segmental glomerulosclerosis (FSGS)
- membranoproliferative GN
4
Q
What systemic conditions can cause a nephrotic syndrome?
A
diabetes mellitus
systemic lupus erythematosus
amyloidosis
5
Q
What 2 drugs are associated with nephrotic syndrome?
A
gold
penicillamine
6
Q
What cancers can cause a nephrotic syndrome?
A
carcinoma
lymphoma
leukaemia
myeloma
7
Q
What infections can cause a nephrotic syndrome?
A
Bacterial endocarditis
hepatitis B
malaria
8
Q
Complications of nephrotic syndrome
A
- increased VTE risk (DVT, OE, renal vein thrombosis)
- hyperlipidaemia (risk of ACS/stroke)
- CKD
- risk of infection due to urinary Immunoglobulin loss
- hypocalcaemia (vitamin D and binding protein lost in urine)
9
Q
A
