post-strep Glomerulonephritis

Question 1

how long after strep infection does this occur?

Answer 1

1-2 weeks
7-14 days

Question 2

Most common strep infection associated with GN?

Answer 2

usually Streptococcus pyogenes.

Question 3

What causes post-strep glomerulonephritis?

Answer 3

immune complex (IgG, IgM and C3) deposition in the glomeruli

Question 4

What age group is most commonly affected?

Answer 4

Young children

Question 5

Clinical features

Answer 5

headache
malaise
visible haematuria
proteinuria
maybe oedema
hypertension
oliguria

Question 6

Findings on blood tests in post-strep glomerulonephritis

Answer 6

• raised anti-streptolysin O titre
• low C3

Question 7

differentiate IgA nephropathy from Post-strep glomerulonephritis

Answer 7

IgA
- young male
- 1-2 days post URTI
- macroscopic haematuria

Post-strep
1-2 weeks after
children
low complement
haematuria but may also have protein/oedema

Question 8

Features of post strep GN on renal biopsy

Answer 8

• endothelial proliferation with neutrophils

electron microscopy:
- subepithelial ‘humps’ caused by immune complex deposits

immunofluorescence:
- granular or ‘starry sky’ appearance

Question 9

Post-strep GN has a good prognosis. TRUE/FALSE?

Answer 9

TRUE