Goodpasture's (Anti-GBM) Flashcards
1
Q
Describe what size of blood vessels are affected in Anti-GBM disease
A
Small vessel vasculitis
2
Q
Common presentation of anti-GBM
A
pulmonary haemorrhage
New AKI - rapidly progressive glomerulonephritis (proteinuria and haematuria)
3
Q
Anti-GBM antibodies are directed against which protein?
A
Type IV collagen
4
Q
More common in males or females?
A
Males (ratio M:F, 2:1)
5
Q
Describe the bimodal age distribution seen in anti-GBM disease
A
peaks in 20-30 and 60-70 age bracket
6
Q
HLA association
A
HLA DR2.
7
Q
Investigations used for diagnosis
A
- Renal biopsy: linear IgG deposits along the basement membrane
- Raised transfer factor secondary to pulmonary haemorrhages
8
Q
finding of anti-GBM on renal biopsy
A
linear IgG deposits along basement membrane
9
Q
Management of anti-GBM
A
plasma exchange (plasmapheresis)
steroids
cyclophosphamide
10
Q
Factors which increase the risk of pulmonary haemorrhage in anti-GBM
A
- smoking
- LRTI
- pulmonary oedema
- inhalation of hydrocarbons
- young males
11
Q
A
