Smooth Muscle Vasoactive Drugs: Prostaglandins, prostacyclin, bosentan PDE5 inhibitors

Question 1

COX-1 and COX-2 produce

Answer 1

prostanoids (e.g. prostaglandins)

Question 2

alprostadil is a

Answer 2

PGE1 agonist

Question 3

alprostadil treats

Answer 3

erectile dysfunction

Question 4

alprostadil is a

Answer 4

vasodilator

Question 5

alprostadil maintains

Answer 5

patent ductus arteriosus

Question 6

NSAIDs (e.g. indomethacin) promote closure of

Answer 6

ductus arteriosus

Question 7

_________ promote closure of ductus arteriosus

Answer 7

NSAIDs (e.g. indomethacin) promote closure of ductus arteriosus

Question 8

misoprostol is a

Answer 8

PGE1

Question 9

PGE1 agonists

Answer 9

1. misoprostol

2. alprostadil

Question 10

misoprostol promotes

Answer 10

1. protective mucus secretion by gastric mucosa

2. uterine contraction to facilitate labor or terminate pregnancy

Question 11

misoprostol can prevent

Answer 11

NSAID-induced peptic ulcer

Question 12

misoprostol can cause

Answer 12

diarrhea

Question 13

dinoprostone is a

Answer 13

PGE2 agonist

Question 14

dinoprostone promotes

Answer 14

uterine contraction and ripens the cervix to facilitate labor or terminate pregnancy

Question 15

carboprost is a

Answer 15

PGF2 inhibitor and stimulator

Question 16

carboprost promotes

Answer 16

uterine contraction to control postpartum hemorrhage or terminate pregnancy

Question 17

_______ promotes uterine contraction to control postpartum hemorrhage or terminate pregnancy

Answer 17

1. Carboprost
2. Dinoprostone
3. Misoprostol

Question 18

PGF2 stimulator and inhibitor

Answer 18

1. Latanoprost
2. Carboprost
3. Travoprost

Question 19

latanoprost and travoprost treat

Answer 19

glaucoma by increasing aqueous humor outflow

Question 20

latanoprost and travoprost can produce

Answer 20

brown pigmentation in iris

Question 21

prostacyclin analogs cause

Answer 21

vasodilation (e.g. iloprost, epoprostenol)

Question 22

iloprost and epoprostenol (prostacyclin analogs) treat

Answer 22

pulmonary hypertension

Question 23

iloprost and epoprostenol may cause

Answer 23

flushing, headache, hypotension

Question 24

_____ suffix of phosphodiesterase isoform 5 (PDE-5) inhibitors (e.g. sildenafil, tadalafil)

Answer 24

-fill

Question 25

phosphodiesterase isoform 5 (PDE-5) inhibitors

Answer 25

1. Sildenafil

2. Tadalafil

Question 26

PDE-5 inhibitors increase

Answer 26

cGMP

Question 27

PDE-5 inhibitors (e.g. sildenafil, tadalafil) treat

Answer 27

1. pulmonary hypertension

2. erectile dysfunction

Question 28

bosentan treats

Answer 28

pulmonary hypertension

Question 29

bosentan is an

Answer 29

endothelin inhibitor

Question 30

bosentan (an endothelin inhibitor) causes

Answer 30

vasodilation

Question 31

bosentan is associated with

Answer 31

fatal hepatotoxicity