Anticoagulants & Thrombolytics: Thrombolytics

Question 1

Alteplase is a

Answer 1

tissue plasminogen activator thrombolytic

Question 2

Streptokinase is a

Answer 2

fibrinolytic

Question 3

Streptokinase is synthesized by

Answer 3

streptococci

Question 4

Plasminogen is converted to plasmin by

Answer 4

TPA and streptokinase

Question 5

Plasmin

Answer 5

degrades fibrin clots

Question 6

Fibrinolytics prolong

Answer 6

1. PT

2. PTT

Question 7

D-dimer is a

Answer 7

fibrin degradation product formed from clot lysis

Question 8

IV fibrinolytics may be used in the setting of

Answer 8

1. an ischemic stroke
2. acute treatment of severe DVT and PE
3. acute management of MI

Question 9

Administer IV fibrinolytics within __________ of ischemic stroke symptoms

Answer 9

3-4.5 hours

Question 10

PCI is the preferred reperfusion option in

Answer 10

acute STEMI

Question 11

Perform PCI ideally within _____ _____ in setting of acute STEMI

Answer 11

2 hours

Question 12

________ _______ ______ is a contraindication for fibrinolytic therapy

Answer 12

1. recent head trauma
2. recent intracranial surgery
3. Severe hypertension
4. Cerebral hemorrhage

Question 13

_________ on CT w/contrast indicates cerebral hemorrhage

Answer 13

enhancement

Question 14

Enhancement on CT with contrast indicates

Answer 14

cerebral hemorrhage

Question 15

Streptokinase can cause

Answer 15

allergic reaction and anaphylaxis

Question 16

Aminocaproic acid can be used to reverse

Answer 16

fibrinolysis

Question 17

Aminocaproic acid

Answer 17

competitively inhibits plasminogen activation

Question 18

Tranexamic acid can be used to reverse

Answer 18

TPA

Question 19

FFP can be used to reverse

Answer 19

coagulopathy

Question 20

Cryoprecipitate can be used to reverse

Answer 20

coagulopathy

Question 21

What 2 agents can be used to reverse coagulopathy

Answer 21

1. FFP

2. Cryoprecipitate