Autonomic Sympathetic Drugs: Beta Blockers

Question 1

Beta blockers are

Answer 1

beta adrenergic receptor antagonists

Question 2

_________ suffix of beta blockers

Answer 2

“-lol”

Question 3

Beta blockers include

Answer 3

1. Propranolol
2. Metoprolol
3. Atenolol

Question 4

Beta blockers decrease

Answer 4

beta blockers decrease cardiac contractility (by antagonizing beta-1 receptors in the myocardium)

Question 5

Beta blockers suppress

Answer 5

beta blockers suppress activity at the SA and AV nodes (by antagonizing beta-1 receptors)

Question 6

Inhibition of SA node activity by beta blockers can cause

Answer 6

bradycardia

Question 7

beta blockers can cause or exacerbate

Answer 7

heart block (due to excessive suppression of AV node conduction)

Question 8

beta blockers are useful in the management of

Answer 8

chronic stable angina

Question 9

beta blockers treat angina by

Answer 9

reducing myocardial oxygen demand (decreased heart rate and contractility)

Question 10

beta-1 selective antagonists

Answer 10

1. Atenolol
2. Betaxolol
3. Esmolol
4. Acebutolol
5. Metoprolol

Question 11

the beta-1 selective antagonists primarily suppress

Answer 11

the beta-1 selective antagonists primarily suppress adrenergic stimulation of the heart (cardioselective)

Question 12

cardioselective beta blockers are useful in the

Answer 12

1. acute treatment of MI and other acute coronary syndromes (ACS)
2. management of chronic heart failure

Question 13

carvedilol (in addition to cardioselective beta blockers) is useful in the management of

Answer 13

chronic heart failure

Question 14

carvedilol is

Answer 14

a nonselective beta blocker and alpha-1 blocker

Question 15

beta blockers (e.g. carvedilol and cardioselective agents) reduce

Answer 15

beta blockers (e.g. carvedilol and cardioselective agents) reduce mortality in chronic heart failure and post-MI

Question 16

beta blockers reduce cardiac remodeling by

Answer 16

beta blockers reduce cardiac remodeling by protecting the heart from excess circulating catecholamines

Question 17

beta blockers are useful in the treatment of

Answer 17

hypertension (especially in patients with heart failure or post-MI)

Question 18

beta blockers inhibit

Answer 18

beta blockers inhibit production of renin (antagonize beta-1 receptors at the JGA)

Question 19

labetalol is a

Answer 19

nonselective beta blocker and alpha-1 blocker

Question 20

labetalol antagonizes

Answer 20

alpha-1 receptors causing vasodilation

Question 21

labetalol treats

Answer 21

hypertension in pregnancy

Question 22

labetalol is useful in hypertensive emergency due to

Answer 22

combined alpha and beta blocking effects

Question 23

IV beta blockers are

Answer 23

1. Labetalol
2. Esmolol
3. Propanolol

Question 24

IV beta blockers

Answer 24

1. treat hypertensive emergency
2. acute management of aortic dissection
3. management of hypertrophic obstructive cardiomyopathy

Question 25

beta blockers can be used for

Answer 25

migraine prophylaxis

Question 26

beta blockers are useful for

Answer 26

beta blockers are useful for the symptomatic treatment of thyroid storm (blocks increased sympathetic activity)

Question 27

beta blockers treat

Answer 27

essential tremor

Question 28

beta blockers have

Answer 28

antiarrhythmic properties

Question 29

nonselective beta blockers can exacerbate

Answer 29

asthma and COPD (antagonize beta-2 mediated bronchodilation)

Question 30

topical nonselective beta blockers include

Answer 30

timolol

Question 31

topical nonselective beta blockers

Answer 31

glaucoma (antagonize beta-2 receptors on the ciliary epithelium → decreased aqueous humor production)

Question 32

beta blockers can cause ______ in men

Answer 32

impotence

Question 33

acebutolol

Answer 33

a selective beta-1 antagonist with partial agonist activity

Question 34

pindolol

Answer 34

a nonselective beta blocker with partial agonist activity

Question 35

beta blockers with partial agonist activity

Answer 35

beta blockers with partial agonist activity (e.g. pindolol, acebutolol) should be avoided in patients with heart failure or a history of MI

Question 36

Glucagon treats

Answer 36

beta blocker toxicity (stimulates heart via glucagon receptors)