Autonomic Sympathetic Drugs: Beta Blockers Flashcards
Beta blockers are
beta adrenergic receptor antagonists
_________ suffix of beta blockers
“-lol”
Beta blockers include
- Propranolol
- Metoprolol
- Atenolol
Beta blockers decrease
beta blockers decrease cardiac contractility (by antagonizing beta-1 receptors in the myocardium)
Beta blockers suppress
beta blockers suppress activity at the SA and AV nodes (by antagonizing beta-1 receptors)
Inhibition of SA node activity by beta blockers can cause
bradycardia
beta blockers can cause or exacerbate
heart block (due to excessive suppression of AV node conduction)
beta blockers are useful in the management of
chronic stable angina
beta blockers treat angina by
reducing myocardial oxygen demand (decreased heart rate and contractility)
beta-1 selective antagonists
- Atenolol
- Betaxolol
- Esmolol
- Acebutolol
- Metoprolol
the beta-1 selective antagonists primarily suppress
the beta-1 selective antagonists primarily suppress adrenergic stimulation of the heart (cardioselective)
cardioselective beta blockers are useful in the
- acute treatment of MI and other acute coronary syndromes (ACS)
- management of chronic heart failure
carvedilol (in addition to cardioselective beta blockers) is useful in the management of
chronic heart failure
carvedilol is
a nonselective beta blocker and alpha-1 blocker
beta blockers (e.g. carvedilol and cardioselective agents) reduce
beta blockers (e.g. carvedilol and cardioselective agents) reduce mortality in chronic heart failure and post-MI
beta blockers reduce cardiac remodeling by
beta blockers reduce cardiac remodeling by protecting the heart from excess circulating catecholamines
beta blockers are useful in the treatment of
hypertension (especially in patients with heart failure or post-MI)
beta blockers inhibit
beta blockers inhibit production of renin (antagonize beta-1 receptors at the JGA)
labetalol is a
nonselective beta blocker and alpha-1 blocker
labetalol antagonizes
alpha-1 receptors causing vasodilation
labetalol treats
hypertension in pregnancy
labetalol is useful in hypertensive emergency due to
combined alpha and beta blocking effects
IV beta blockers are
- Labetalol
- Esmolol
- Propanolol
IV beta blockers
- treat hypertensive emergency
- acute management of aortic dissection
- management of hypertrophic obstructive cardiomyopathy
beta blockers can be used for
migraine prophylaxis
beta blockers are useful for
beta blockers are useful for the symptomatic treatment of thyroid storm (blocks increased sympathetic activity)
beta blockers treat
essential tremor
beta blockers have
antiarrhythmic properties
nonselective beta blockers can exacerbate
asthma and COPD (antagonize beta-2 mediated bronchodilation)
topical nonselective beta blockers include
timolol
topical nonselective beta blockers
glaucoma (antagonize beta-2 receptors on the ciliary epithelium → decreased aqueous humor production)
beta blockers can cause ______ in men
impotence
acebutolol
a selective beta-1 antagonist with partial agonist activity
pindolol
a nonselective beta blocker with partial agonist activity
beta blockers with partial agonist activity
beta blockers with partial agonist activity (e.g. pindolol, acebutolol) should be avoided in patients with heart failure or a history of MI
Glucagon treats
beta blocker toxicity (stimulates heart via glucagon receptors)
