Skeletal Flashcards
The skeletal system is made of
bones and cartilage
Most skeletal cancers are
metastatic
Most skeletal tumors originate in the
mesoderm, primitive mesenchyme, and ectoderm cells
skeletal Tumors commonly occur in areas where rapid growth is occurring, such as the
growth plate
Most skeletal tumors occur in the distal femur and proximal tibia because they have the
largest growth plates
The ___of a long bone is the main shaft
diaphysis
The _____are two knob-like portions of the bone at either end
epiphyses
The ______is the hard covering on the bone
periosteum
The Common sites for osteosarcomas are:
distal femur, proximal tibia, and proximal humerus
The Common sites for chondrosarcomas are :
femur, shoulder girdle, and proximal humerus
The Common sites for malignant fibrous histiocytomas (MFH) or fibrosarcomas are :
long, tubular bones like the femur or tibia
The Common sites for Ewing’s sarcoma are :
lower half of the body in the diaphysis of the bone
The Common sites for metastatic tumors from skeletal is :
vertebral bodies, pelvic bones, and ribs
_____is the most common clinical presentation of bone tumors
Pain
_______is the most common bone tumor
Osteosarcoma
- occur in children teens and young adults
Skip metastasis is common for
osteosarcomas
etiology for primary bone and soft tissue Is ?
- radiation exposure
- genetic disorders
- viruses
- development abnormalities
clinical symptoms for bone and soft tissues
- pain
- mass
- swelling
- fracture
- nerves
- weight loss
histology for bone cancers
fibrosarcomas
osteosarcomas
chondrosarcomas
Ewing sarcoma
hemangiosarcoma
chordoma
epidomiology for osteosarcoma
- adolescents and young adults
epidemiology for chondrosarcoma
- over 50 years old; incidence increases with age
- occur in pelvis vertebrae long bones and shoulders
epidemiology for fibrosarcoma/malignant fibrous histiocytoma
very rare - 6-81 yrs most older than 40 age
epidemiology for round cell/ Ewing sarcoma
Ewing occurs in childhood; age range 10-30 yrs old
- occur in pelvis chest wall and legs
epidemiology for Giant cell
usually benign; shows up in the metaphysis or epiphysis of long bones in young adults
multiple myeloma epidimiology
actually a blood malignancy originating in bone marrow: elderly affected the most; solitary - known in plasma