Seminar G Polyarteritis Nodosa Flashcards
1
Q
Definition
A
A rare systemic illness characterised by necrotising inflammation of medium-sized arteries leading to aneurysm formation.
Principally affects viscera, and may lead to organ infarction if left untreated
2
Q
Clinical Features
A
Fever
Weight loss
Malaise
GI upset
Vasculitic rash
Renal, pulmonary and CVS involvement may also occur
Peripheral neuropathy may also occu, due to involvement of the vasa nervorum
3
Q
Association with
A
HEP B infection
4
Q
Clinical diagnosis may be confirmed either by
A
Histological analysis of affected organs
Coeliac axis or renal arteriograms (beading pattern of microaneurysms)
5
Q
Treatment →
A
High-dose glucocorticoids usually with pulsed cyclophosphamide therapy
