Seminar G Antiphospholipid antibody

Question 1

Clinical Manifestations

Answer 1

1. Venous and arterial thrombosis
2. Thrombocytopenia
3. Recurrent fetal loss (especially 2nd trimester)
4. Cerebral disease (e.g. migraine, seizures)
5. Livedo reticularis (see rash sheet)

Question 2

Syndrome confirmed by detection of

Answer 2

• Anticardiolipin
• Antiphospholipid antibodies in the serum
• Lupus anticoagulant presence

Question 3

Treatment

Answer 3

Anticoagulation with either aspirin or warfarin or both

Many female sufferes have been able to carry foetuses to term as a result