FN: Anti-phospholipid Syndrome Flashcards
1
Q
Classificatoin
A
Primary: 70%
Secondary to SLE: 30%
2
Q
Pathology
A
Anti-phospholipid Abs: anti-cardiolipin and lupus anticoagulant
3
Q
Features
A
- CLOTS: venous (e.g. DVT) and arterial (e.g. stroke)
- Coagulation defect: increase APTT
- Livido reticularis
- Obstetric complications: recurrent 1st trimester abortion
- Thrombocytopaenia
4
Q
Treatment
A
Low dose aspirin
Warfarin if recurrent thrombosis: INR 3.5
5
Q
Management
A
in specialist SLE and lupus nephritis clinics
6
Q
Sever flares: Acute SLE
A
AIHA, nephritis, pericarditis or CNS disease
High-dose prednisolone and IV cyclophosphamide
7
Q
Cutaneous symptoms
A
Treat with topical steroids and prevent with sun cream
8
Q
Maintenance
A
For joint and skin symptoms
NSAIDS and hydroxychloroquine and lose dose steroids
9
Q
Lupus Nephritis
A
Proteinuria:ACEi
Aggressive GN: immunosuppression
10
Q
Treatment complications
A
Increased risk of osteoporosis and CV disease
11
Q
Prognosis
A
80% survival @ 15 yrs
