Seizures Flashcards
1
Q
Drugs that can lower seizure threshold
A
Bupropion Tramadol Clozapine Varenicline Lithium Carbapenems FQs Penicillins
2
Q
GABA
A
Inhibitory neurotransmitter
3
Q
Glutamate
A
Excitatory neurotransmitter
4
Q
Drugs that increase GABA (for epilepsy)
A
BZDs
Valproic acid
5
Q
Drugs that are Na channel blockers (for seizures)
A
Decreases neuron firing rate
- phenytoin/fosphenytoin
- lamotrogine
- topiramate
- carbamazepine
6
Q
Drugs that block Ca channels (for seizures)
A
Slows down/stops transmission of electrical signals
-ethosuximide
7
Q
Lamotrogine DIs
A
Valproic Acid increases lamotrogine by 2x
-blue starter kit (lower dose)
Carbamazepine, phenytoin, phenobarbital decrease lamotrogine by 40%
-green starter kit (higher dose)
8
Q
Phenytoin correction equation
A
Saturable kinetics (Michaelis-Mentin)
Total phenytoin measured
(0. 2 x albumin) + 0.1
