Anticoagulation

Question 1

For pts with NON-cardioembolic ischemic stroke or TIA, recommend a _________

Answer 1

Antiplatelet (rather than anticoagulant)

Question 2

Warfarin inhibits which clotting factors

Answer 2

2, 7, 9, 10

Question 3

DOACs inhibit which clotting factor

Answer 3

Xa

Question 4

MOA of Dabigatran

Answer 4

Direct thrombin inhibitor

Question 5

Heparin MOA

Answer 5

Inhibit Xa and thrombin IIa

Question 6

Vit K role in anticoagulation

Answer 6

Required for carboxylation (activation) of clotting factors 2, 7, 9, 10

Question 7

Signs of a stroke

Answer 7

FAST
Face
Arms
Speech 
Time

Question 8

LMWHs

Answer 8

More predictable anticoagulation response than UH and no Anti-Xa level monitoring in most cases

• Enoxaparin (Lovenox)
• Dalteparin (Fragmin)

Question 9

Which doses of Xarelto have to take with food

Answer 9

If equal to or greater than 15mg

Question 10

INR over 10 w/o bleeding

Answer 10

Give oral vit K 2.5-5mg

Question 11

If major bleed on warfarin

Answer 11

Give vit K 5-10mg slow IV

Question 12

Treatment for pts with mechanical heart valves

Answer 12

Highest clot risk

Only treat with warfarin

Question 13

CHADS-VASC

Answer 13

CHF
HTN
Age greater than or equal to 75 (2 pts)
DM
Stroke/TIA hx (2 pts)

Vasc dx (MI, PAD, aortic plaque)
Age 65-74
Sex F

Question 14

Anticoagulation in pregnancy

Answer 14

LMWHs and monitoring anti-Xa levels recommended