Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

RxPrep NAPLEX > Depression > Flashcards

Depression Flashcards

1
Q

DSM5 criteria

A 
Requires at least 5 during a 2wk period
M SIG E CAPS
-mood
-sleep
-interest/pleasure
-guilt/worthlessness
-energy
-concentration
-appetite
-psychomotor agitation/retardation
-suicidal ideation
MUST INCLUDE EITHER MOOD OR INTEREST
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Neurotransmitters involved in depression

A 
Serotonin
Glutamate 
Acetylcholine 
Dopamine
Norepinephrine 
Epinephrine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Drugs that cause/worsen depression

A 
Atomoxetine
Indomethacin
Efavirenz (Atripla)
BBs (propranolol)
OCPs
Varenicline 
Cyclosporine
Clonidine
Isotretinion
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Antidepressants in breastfeeding

A

SSRIs

Tricyclics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Preferred SSRI if cardiac risk

A

Sertraline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Most sedative SSRI

A

Paroxetine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Most activating SSRI

A

Fluoxetine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

SSRI and 5-HT1A partial agonist

A

Vilazodone (Viibryd)

-take with food

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

SSRI and 5-HT1A agonist and 5HT receptor antagonist

A

Vortioxetine (Trintellix)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

SNRIs

A

Venlafaxine
Duloxetine
Desvenlafaxine (Pristiq)
Levoomilnacipram (Fetzima)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

MOA of tricyclics

A

Inhibit NE and serotonin reuptake, plus block acetylcholine and histamine receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Secondary amines

A

Nortiptyline

Desipramine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Tertiary amines

A 
More effective, but worse SEs (more anticholinergic, weight gain, sedation)
Amitriptyline
Doxepin
Clomipramine 
Imipramine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Bupropion MOA

A

Dopamine and NE reuptake inhibitor

-no effect on serotonin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

CI for bupropion

A

Seizures

Anorexia/bulimia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

SE for bupropion

A

Dry mouth
Insomnia
Weight loss
CNS stimulant

17
Q

MAOIs

A

Isocarboxazid
Phenelzine
Tranylcypromine

18
Q

MAOIs MOA

A

Monoamine oxidase breaks down catecholamines; 5HT, NE, DA, EPI

If these NTs increase dramatically = HTN crisis

19
Q

MAOIs counselling points

A

SE: anticholinergic, orthostasis, sedation, sexual dysfunction, weight gain
Must avoid tyramine-rich foods: aged, fermented, pickled, smoked

20
Q

Meds that require 2 wk washout period with MAOIs

A

SSRIs (5wk for fluoxetine)
SNRIs
TCAs
Bupropion

21
Q

Depression meds if trying to avoid sexual dysfunction

A

Bupropion

Mirtazipine

22
Q

MOA of mirtazapine

A

Tetracyclic antidepressant

-increases 5HT and NE

23
Q

SE of mirtazapine

A

Weight gain
Sedation
Increased appetite
Anticholinergic

24
Q

Serotonin syndrome SE

A 
HA
N
D
Dizziness
Increased heart rate
Hallucinations
25
Q

Only antipsychotic approved for treatment resistant depression

A

Olanzapine + Fluoxetine (Symbian)

RxPrep NAPLEX (33 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions