Schizophrenia

Question 1

Extrapyramidol SE (EPS)

Answer 1

A group of sx related to irregular movements

• dystopias
• akathsias
• Parkinsonism

Question 2

Treatment for EPS

Answer 2

Anticholinergics

• benztropine
• diphenhydramine

Question 3

DSM5 for schizophrenia

Answer 3

Negative sx: 
-decreased interest
-lack of emotion/speech
-social withdrawal
-loss of motivation
Positive sx: ONE MUST BE PRESENT
-hallucinations
-delusions
-disorganized thinking/behavior

Question 4

Schizophrenia MOA

Answer 4

Altered brain structure/chemistry involving increased DA and glutamine

Question 5

Difference in SE of first gen and second gen antipsychotics

Answer 5

FGA: increased EPS, decreased weight gain/metabolic SEs
SGA: decreased EPS, increased weight gain/metabolic SEs

Question 6

Differences in mechanisms of FGA and SGA

Answer 6

Both block DA

Second Gen also block 5HT receptors moreso than First Gen

Question 7

Low potency FGA

Answer 7

Chlorpromazine

Thioridazine

Question 8

Mid potency FGA

Answer 8

Loxapine

Perphenazine

Question 9

High potency FGA

Answer 9

Haloperidol

Fluphenazine

Question 10

Lowest risk of EPS

Answer 10

Quetiapine

Question 11

Highest risk of EPS

Answer 11

FGAs
Risperidone
Paliperidone

Question 12

Lowest risk of metabolic SEs

Answer 12

FGAs
Aripiprazole
Ziprasidone

Question 13

Highest risk of metabolic SEs

Answer 13

Clozapine
Olanzapine
Quetiapine

Question 14

Highest risk of QT prolongation

Answer 14

Haloperidol
Thioridazine
Ziprasidone

Question 15

Highest risk of Stroke/TIA

Answer 15

Risperidone

Question 16

Highest risk of increased prolactin

Answer 16

Risperidone

Paliperidone