GERD

Question 1

drugs that can worsen GERD sx

Answer 1

NSAIDs
Iron
Bisphosphonates
Steroids
Tetracyclines
Nicotine replacement
Dabigatran
Fish oil
Estrogen products

Question 2

Formulations available IV for GERD

Answer 2

Famotidine
Esomeprazole
Pantoprazole

Question 3

Which PPIs can decrease effectiveness of clopidogrel

Answer 3

Omeprazole

Esomeprazole

Question 4

Which kind of ulcer’s pain is lessened by eating food

Answer 4

Duodenal - H. Pylori

Question 5

1st line tx for H Pylori

Answer 5

Bismuth Subsalicylate 300mg QID
Metronidazole 250-500mg QID
Tetracycline 500mg QID
PPI BID

-taken for 10-14 days

Question 6

drugs that are constipation get

Answer 6

Aluminum antacids
Verapamil
Anticholinergics
Clonidine 
Iron
Opioids
Sucralfate (contains an aluminum complex)

Question 7

Oral stimulants in constipation

Answer 7

Senna and bisacodyl

-take about 10 hrs to work (take HS with BM in morning)

Question 8

Osmotics for constipation

Answer 8

PEG 3350
Magnesum hydroxide (MOM), citrate, sulfate
Laculose
Glycerin
Sorbitol
-large ions/molecules that are poorly absorbed so draws fluid into the bowel lumen through osmosis which distends the colon and increases peristalsis

Question 9

Drugs that cause diarrhea

Answer 9

Magnesium 
Misoprostol
Antibiotics
Metoclopramide 
Quinidine 
Colchicine 
Antineoplastics

Question 10

Peripherally-acting mu-opioid receptor antagonists (PAMORAs)

Answer 10

Only used in pts taking opioids for constipation

• naloxegol (movantik)
• methylnaltrexone (relistor)
• naldemedine (symproic)