Hepatitis & Liver Disease

Question 1

Hep A transmission

Answer 1

Fecal-oral

Question 2

Hep B and C transmission

Answer 2

Blood, body fluids

Question 3

General tx for Hep B

Answer 3

PEG-INF or NRTI

Question 4

General Tx for Hep C

Answer 4

DAAs combo (2-3)

Question 5

Ritonavir role in Hep C

Answer 5

Not active against Hep C but used to boost levels of HCV protease inhibitors used with it

Question 6

DAA stands for

Answer 6

Direct acting antiviral

Question 7

DAAs used for HCV Regimends

Answer 7

1. NS3/4A Protease Inhibitors
2. NS5A Replication Complex Inhibitor
3. NS5B Polymerase Inhibitors

Question 8

NS3/4A Protease Inhibitors

Answer 8

P for PI, “-previr”
Grazoprevir
Paritaprevir

Question 9

NS5A Replication Complex Inhibitor

Answer 9

A for NS5A, “-asvir”
Daclatasvir
Ledipasviir

Question 10

NS5B Polyerase Inhibitor

Answer 10

B for NS5B, “-buvir”
Dasabuvir
Sofosbuvir

Question 11

What is never used as monotherapy in HCV

Answer 11

Ribavirin

-teratogenic, anemia

Question 12

What are interferons

Answer 12

Naturally-produced cytokines that have antiviral, antiproliferative, and immunomodulatory effects

• not 1st line for HCV anymore due to toxicities (flu-like sx) and lab abnormalities
• used in HBV moreso

Question 13

HBV tx NRTIs

Answer 13

Can be used to treat both HBV and HIV

• tenofovir disoproxil - 1st line
• tenofovir alafenamide

Question 14

Most common cause of cirrhosis

Answer 14

Alcohol and HCV

Question 15

Albumin is produced in the

Answer 15

Liver

Question 16

Lab values that indicate alcoholic liver disease

Answer 16

Double AST (compared to ALT) and increased GGT

Question 17

Drugs with boxed warning for liver damage

Answer 17

APAP (high doses)
Isoniazid 
Ketoconazole
Methotrexate
Nefazodone
Nevirapine
NRTIs
Propylthiouracil
Tipranavir
Valproic Acid

Question 18

Wenicke-Korsakoff syndrome is caused by

Answer 18

Lack of vitamin B1 (thiamin)