Hypertension

Question 1

Drugs that increase BP

Answer 1

Amphetamines/ADHD meds
Decongestants
Erythropoiesis Stimulating Agents
Immunosuppressants (cyclosporine)
NSAIDs
Steroids

Question 2

Preferred drug class, that is NOT first line for African-Americans

Answer 2

ACE and ARBs

Question 3

Hypertension tx in pregnancy

Answer 3

Labetolol
Methyldopa
Nifedipine XR

Question 4

Thiazides type diuretics

Answer 4

HCTZ
Chlorthalidone
Indapamide
Metolazone

Question 5

Thiazides MOA

Answer 5

Inhibit Na reabsorption, so increases excretion of Na, H20, K, and Cl

Question 6

Thiazides notes

Answer 6

CI if sulfa allergy
Decreases potassium
All not effective if CrCl <30 (except metolazone)
Sun sensitivity

Question 7

DHP CCBs MOA

Answer 7

Inhibit Ca ions from entering vascular smooth muscle and myocardial cells causing peripheral arterial vasodilation

Question 8

Non-DHP CCBs MOA

Answer 8

Same as DHP CCBs but more selective for the myocardium

-diltiazem and verapamil

Question 9

Angiotensin II role

Answer 9

Causes vasoconstriction and increases aldosterone (Na and H20 retention)

Question 10

BBs with ISA

Answer 10

Acebutolol
Pindolol
Penbutolol
-partially stimulate beta receptors, while blocking the effects of catocholamines (NE)
-do not lower HR as much

Question 11

BBs of choice in HF

Answer 11

Bisoprolol
Carvedilol
Metoprolol succinate

Question 12

B1 selective BBs

Answer 12

AMEBBA
Acebutolol
Metoprolol
Esmolol
Bisoprolol
Betaxolol
Atenolol

Question 13

Non-selective BBs

Answer 13

Nadolol
Propranolol
Timolol
Pindolol

Question 14

Non-selective and Alpha1 blocking BBs

Answer 14

Carvedilol

Labetalol

Question 15

BB that has to be taken with food

Answer 15

Carvedilol

-all forms

Question 16

Centrally acting alpha2 adrenergic agonists

Answer 16

Clonidine
Methyldopa
Guanfacine
-decreases NE in brain which decreases HR

Question 17

HTN crisis

Answer 17

Over 180/120

Question 18

Direct vasodilaters

Answer 18

Hydralazine

Minoxidil