Misc

Question 1

Drugs causing photosensivity

Answer 1

Amiodarone
Diuretics
MTX
Retinoids 
Quinolones
Tetracyclines
Sulfa
Tacrolimus
Voriconazole

Question 2

Thrombotic Thrombocytopenic Purpura (TTP) -clotting process - known with

Answer 2

Clopidogrel

SMX

Question 3

Drugs commonly associated with severe skin reactions

Answer 3

Abacavir
Allopurinol
Phenytoin
Carbamazepine 
Ethosuximmide
Penicillins
Lamotrogine
Modafinil
Topimax

Question 4

Epipen Jr dose (0.15mg) used for _____________kg

Answer 4

15-30kg

Question 5

What does micronizing a drug do?

Answer 5

For drugs with poor absorption

-increases dissolution rate by decreasing particle diameter which increases surface area

Question 6

AUC is

Answer 6

The total exposure of drug following administration

Question 7

Drug characteristics with increase distribution

Answer 7

Low MW
High lipophilicity
Low protein binding
Unionized

Question 8

Vd =

Answer 8

Conc of drug in plasma

Question 9

Process by which a drug is converted from its original chemical structure into other forms to facilitate with elimination

Answer 9

Metabolism

Question 10

Phase I rxns

Answer 10

Oxidation
Hydrolysis
Reduction

Question 11

Phase II rxns

Answer 11

Conjugation

Question 12

Cl =

Answer 12

Conc

Question 13

F if IV

Answer 13

1

Question 14

F x Dose = Cl X AUC

Answer 14

Remember dat

Question 15

Constant PERCENTAGE of drug is removed per unit of time

Answer 15

First-order kinetics

-majority of drugs

Question 16

Constant AMOUNT of drug is removed per unit of time

Answer 16

Zero-order kinetics

Question 17

Ke

Answer 17

Elimination rate constant

Question 18

Ke =

Answer 18

Vd

Question 19

Half life (t1/2) =

Answer 19

Ke

Question 20

When the rate of drug intake = the rate of drug elimination

Answer 20

Steady state

Question 21

When is steady state reached

Answer 21

About 5 half-lives

-when more than 95% of the drug in eliminated