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RxPrep NAPLEX > Dyslipidemia > Flashcards

Dyslipidemia Flashcards

1
Q

Ideal parameters for checking lipoprotein labs

A

After a 9-12 hour fast

-if not, TG levels could be falsely elevated

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2
Q

Drugs that increase LDL and TGs

A

Protease inhibitors
Steroids
Diuretics
Immunosuppressants (cyclosporine, tacrolimus)

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3
Q

Drugs that increase LDL only

A

Fibrates

SGLT2 Inhibitors

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4
Q

Drugs that increase TGs only

A

IV lipid emulsions, propofol
BBs
Atypical antipsychotics

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5
Q

Non HDL goal

A

<130

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6
Q

TGs goal

A

<150 is normal

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7
Q

LDL goal

A

<100

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8
Q

HDL goal

A

<40 is low for men

<50 is low for female

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9
Q

OTC fish oil effect on lipids

A

Decrease TGs, but may increase LDL

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10
Q

Lovaza

A

Omega-3 Acid Ethyl Esters

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11
Q

Vascepa

A

Icosapent ethyl

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12
Q

High-intensity statins

A

Atorvastatin 40-80mg
Rosuvastatin 20-40mg

-decrease LDL by more than 50%

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13
Q

MOA of statins

A

Inhibit HMG-CoA reductase, which prevents conversion to mevalonate
-this is the rate-limiting step in cholesterol synthesis

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14
Q

Statins that HAVE to be taken in the evening

A

Simvastatin

Lovastatin

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15
Q

MOA of ezetimibe

A

Inhibits absorption of cholesterol in the small intestine

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16
Q

Proprotein Convertase Subtilisin Kexin Type 9 Inhibitors (PCSK9)

A

Avirocumab (Praluent)
Evolocumab (Repatha)
-increase the # of LDL receptors available to clear LDL (decrease LDL by 60%)

17
Q

Bile Acid Sequestrants/Binding Resins

A

Colesevelam (Welchol)
Cholestyramine (Prevalite, Questran)
Colestipol (Colestid)

18
Q

MOA of bile acid sequestrants

A

Bind bile acids in the intestines forming a complex that is excreted in the feces
-bile acids contain free cholesterol

19
Q

Fibrates ___ TGs, and ___ LDLs

A

Decrease TGs, increase LDLs

20
Q

Fibrates use with statins and ezetimibe

A

Do not use

-increase risk of rhabdo

21
Q

Niacin effect on lipids

A

Decreases TG and LDL

RxPrep NAPLEX (33 decks)

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