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RxPrep NAPLEX > Pysch > Flashcards

Pysch Flashcards

1
Q

BZDs of choice in the elderly

A

LOT- safer in the elderly and those with liver impairment since they are metabolized to inactive glucoronides

  • lorazepam
  • oxazepam
  • temazepam
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2
Q

Best BZDs for anxiety

A

CLAD

  • clonazepam
  • lorazepam
  • alprazaolam
  • diazepam
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3
Q

Best BZDs for sleep

A

Lorazepam

Temazepam

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4
Q

Drug for OD of BZDs

A

Flumazenil

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5
Q

When to taper BZDs?

A

If using regularly, for longer than 10 days

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6
Q

BZDs for alcohol withdrawal

A

Lorazepam
Diazepam
Chlordiazepoxide

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7
Q

Best drugs for falling asleep

A

Eszopiclone
Zolpidem
Ramelteon
Zaleplon

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8
Q

Best drugs for staying asleep

A

Eszopiclone
Zolpidem
Doxepin
Suvorexant

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9
Q

Eszopiclone, zaleplon, zolpidem MOA

A

Non-BZDs

-act selectively and BZDs receptors to increase GABA

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10
Q

Doxylamine

A

Unison

-antihistamine used for sleep

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11
Q

Dopamine-blocking drugs that can worsen Parkinsons

A

Prochlorperazine
Metoclopramide
1st/2nd gen antipsychotics
(Decreased risk with quetiapine, but metabolic SEs)

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12
Q

Sx for Parkinsons

A

TRAP

  • tremor
  • rigidity
  • akinesia/bradykinesia
  • postural instability/falls
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13
Q

COMT inhibitor

A

Entacapone

  • increases duration of action of levodopa
  • ONLY USED WITH LEVODOPA
  • decrease dose of levodopa 10-30% when adding-on
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14
Q

Dopamine agonists

A

Ropinorole (Requip)
Pramipexole (Mirapex)
-slow titration due to orthostasis and somnolence
-bromocriptine no longer used
-SE: orthostasis, somnolence, hallucinations, impulse control

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15
Q

Amantadine

A

Blocks DA reuptake

-primarily used to tx dyskinesias associated with peak-dose Sinemet

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16
Q

Selective MAO-B inhibitors

A

Block breakdown of DA

  • used as adjunctive tx to Sinemet
  • selegiline (activating SEs)
  • rasagiline (can be used as monotherapy)
  • safinamide
17
Q

Benztropine in Parkinsons

A

Primarily used for tremor

-centrally acting anticholinergic

18
Q

Parkinsons disease MOA

A

Occurs when neurons in the substantia nigra die/become impaired
-these cells produce DA which allows smooth coordinated function of body muscles and movement

19
Q

Alzheimer’s disease MOA

A

Involves neuritic plaques and tangles in brain tissue which interrupt neuron signalling, and/or alteration of transmitters
-DECREASES ACETYLCHOLINE

20
Q

Acetylcholinesterase inhibitors

A 
Donepezil
Rivastigmine 
Galantamine
-SEs: insomnia, NVD, wt loss, tremor
CAUTION WITH LOW HR
21
Q

Memantine MOA

A

Blocks NMDA receptors which decreases glutamate

RxPrep NAPLEX (33 decks)

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