Science Of Addiction

Question 1

Drugs that produce
physical dependence = ie. Psycial withdrawal symptoms (diarrhoea, convulsions)

Answer 1

Heroin
Alcohol

Question 2

Drugs that produce
Psychological dependence =
Agitation, depression, CRAVING

Answer 2

Cocaine

Amfetamines

Question 3

Determinants of addiction
2

Answer 3

1. Genetics
   - A1 allele for DA Receptor DRD2 gene is common in people with alcohol or cocaine use disorder 🤔

• alcohol use disorder is rare in people homozygous for ALDH2*2 allele

2. Psychological, environmental

Question 4

2 theories of addiction

Answer 4

1. Negative reinforcement theory
   = repeating behaviour that allows escape from a negative event
2. Positive reinforcement theory
   = repeating behaviour that leads to satisfying outcome

Question 5

How do active drug work?

Answer 5

DA in MESOLIMBIC pathway = critical role in addiction

Drugs of addiction short cut this natural pathway of reward and take a stronger hold over behaviour

Addictive drugs increase DA IN NUCLEUS ACCUMBENS

NO DA in ventral stratum

Question 6

Does D1 OR D2 Receptor have a higher affinity affinity dopamine?

Answer 6

D2

Question 7

Biopyschosocial model of addiction

Answer 7

Biological + psychological + social