Phenytoin Flashcards
1
Q
Is the half lofe clinically useful?
A
No.
Because it is DOSE DEPENDANT
2
Q
Non- dose related side effects
A
Gingival hyperplasia
Hirsutisum
Vit D DEFICIENCY
Folic acid deficiency
Peripheral neuropathy (loss of neural fibres)
3
Q
Mediated by which CYP?
A
CYP2C9
4
Q
Dose change for POOR METABOLISERS of CYP2C9
A
50% reduction of dose
5
Q
Why monitor 😕
A
- Highly protein bound = any factor can change the protein binding.. which alters the free drug
