EBCM : MIGRAINE

Question 1

Define migraine headaches

Answer 1

Neuromuscular headache
A complete primary brain disorder
Involves inappropriate activations of the trigeminocervical pain system

Question 2

Triggers of migraine

Answer 2

Auditory
Fatigue
Gastinf
Stress
Hormonal
Food

Question 3

What are certain food triggers
5

Answer 3

Phenylethyamine
Tryamine
Aspartate
Alcohol
Monosodium glutamate (MSG)
Caffeine

Question 4

Level B
Probably effective
Migraine prophylaxis
CM?
3

Answer 4

Feverfew
Magnesium
Riboflavin (Vitamin B2)

Question 5

What is feverfew?

Form?

Answer 5

Herb
Rich in sesquiterpene lactones
(Parthenolide)

Form: MIG-99 specific extract

Question 6

MOA of feverfew

Answer 6

Inhibits 5HT release from platelets and potential COX and LOX inhibition

Question 7

Feverfew

Long term SIDE EFFECTS

Answer 7

Mouth ulcers and GI symptoms

Question 8

Feverfew

Interactions

Answer 8

CYP3A4
Avoid WARFARIN, ASPRIRIN, NSAIDs

AND

CEASE 2 weeks before surgery

Question 9

What is Riboflavin?

Answer 9

Water soluble B vitamin

Component of 2 flavin coenzymes
- FLAVIN ADENINE DINUCLEOTIDE (PAD)
- FLAVIN MONONUCLEOTIDE (FMN)

Question 10

Can preg or lactating take Riboflavin?

Answer 10

No

Question 11

When is magnesium CONTRAINDICATED

Answer 11

In heart block and renal failure

Question 12

What is the benefit of co enzyme Q10?

Answer 12

Reduce Migraine days and decrease attack frequency

Question 13

What is Co enzyme Q10

Answer 13

Enzyme cofactor made by all cells in the body from tyrosine