Glutamate Neurotransmission

Question 1

Explain the process of
ON AND OFF SWITCH

Answer 1

Excitation =
Influx of Na+ ions = depolarisarion = membrane potentials become more positive = ON SWITCH

Inhibition =
Influx of Cl- ions = hyperpolarisation = membrane potential become more negative = OFF SWITCH

Question 2

How is Glutamate transported out or the synapse?

Answer 2

Must first transport into the ASTROCYTE and convert into GLUTAMINE

Question 3

How to activate Glutamate receptors?

Answer 3

You need Glutamate and Glycine

Question 4

Glutamate receptors

Answer 4

AMPA = fast activation

NMDA = slow activation

Question 5

Glutamate receptors

AMPA
Kainate
NMDA

Agonists

Answer 5

AMPA = glutamate, AMPA

Kainate = glutamate, kainate

NMDA = glutamate, NMDA, aspartate

Question 6

NMDA Receptor 3 distinct sites!!!?

Answer 6

1. Principle site = that opens the channel when bound by glutamate
2. Glycine site which also must be occupied for the channel to open
3. Polyamine binding site that potentates NMDA Receptor activity when both glycine and glutamate sites are