Endocannabinoid System

Question 1

What is the endocannabinoid system responsible for?

Answer 1

Sleep and circadian rhythms
Analgesia
Positive mood
Energy balance
Stree coping

Question 2

Are endocannabinoids synthesised on demand?

Answer 2

Yes

Question 3

Levels of endocannabinoids are tightly regulated by which enzymes?

Answer 3

Synthetic and catabolic enzymes

Question 4

Where are CB1 expressed?

Answer 4

Brain
Lungs
Muscles
GUT
Reproductive organs

Question 5

Where are CB2 expressed?

Answer 5

Brain (microglia)
Tonsils
Skin
Bones
Spleen

Question 6

Cannabinoid receptors-
What does delta9-THC mimic?

Answer 6

Mimics endocannabinoids and activates CB1 receptors

They are abundant in brain (cortex, hippocampus, stratum, mid brain) LOW IN BRAINSTEM

Question 7

Where are CB1 receptors located?

Answer 7

Presynaptic

Question 8

Are endocannabinoid synthesised on demand?

Answer 8

Yes on demand by LIPIDS

Question 9

How does endocannabinoids reduce pain?

Answer 9

Endocannabinoida and CB receptors are found on pain pathways

Therefore CB1 and CB2 have anti-nociceptive effects

Question 10

Paracetamol and NSAID effects on pain via CB receptors

Answer 10

The drugs are Inhibitors of FAAH which degrade anandamide
And
Increase endocannabinoids

Question 11

Examples of endocannabinoid dysrefulstion in diseases
2

Answer 11

Reduced CB1 we expression in the brain
In

1. Huntingtons disease
2. Autism