Multiple Sclerosis Flashcards
1
Q
Pathology of MS
3
A
- Peripheral priming of T cells by environmental factors
- Migration of T cells across BBB in genetically susceptible host
- Local expression of proinflammatory mediators leads to mylein damage, leucocyte inclination across BBB, chemokine release = central damage
2
Q
Risk Factors for MS
A
- Age (20- 40)
- Family
- FEMALE
- Infection (Epstein- Barr virus)
Ethnicity (white)
3
Q
Drug treatment for MS
A
Corticosteroids
(Prednisolone)
IV immunoglobulin
4
Q
Drugs to prevent future attacks (help reduce qttack by 33%)
A
- immune modulating drugs
(Interferon Beta 1a) - Glatirqmer acetate
(Synthetic combo of 4 amino acids) - FINGOLIMOD
(Immune trafficking agents)
* non- selective target of S1P
(lots of ADE)
= prodrug
= no disability progression for 12 months! - SIPONIMOD
= modulation of lymphocyte S1P1 receptors
= selective for 1, 5, SIP receptors
5
Q
Monoclonal antibodies
Name 3
Moa
A
Natalizumab
= binds alpha-4-beta-1 protein
Alemtuzmab
= binds to antigen CD52 (on surface of B qnd T cells) and kills them (lymphocyte depletion)
Ocrelizumab
= binds to CD20 on B lymphocytes (depletion)
6
Q
Which VIRUS in prevalent amongst MS patients
A
John Cunningham (JC) Virus
57% prevalence
7
Q
Highest ranking efficacious drug therapy for MS
A
- Natalizumab
- Fingolimod
