Depression

Question 1

Neurobiology of depression

Answer 1

Reduced activity in noradrenergic and serotonerfic neurotransmission leads to

Hyperactivity of HPA (HYPOTHALAMIC-PITUITARY-ADRENAL) axis ie. Increased cortisol

+

Inflammatory response system

Question 2

Drug structure of TCA

Answer 2

1. Butterfly 🦋 ring shape
2. Protonayed distal NITROGEN
3. Aromatic ring

BINDS TO
SERT
NET
MONOAMINE4GIC RECEPTORS

METBOLISED BY
N-desmethyl analogues

Question 3

SSRI
S-enantiomer or R-
Is more potent?

Answer 3

S