Drugs that Induce SLEEP Flashcards

1
Q

Awake promoting neurochemicals
6

A

ACh
NE
DA
His
5HT
OR

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2
Q

Sleep promoting neurochemicals
5

A

GABA
Adenosine
PGD2
Cytokines
Galanin

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3
Q

Pharmacology behind drugs used in sleep disorders
4 ways

A
  1. Enhance that activity of the VLPO
  2. Supress the activity of acendinf arousal
  3. Enhance circadian drive to sleep
  4. Work on the endocannabinoid system
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4
Q

SUVOREXANT

A

OX1,OX2 Receptor Antagonist

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5
Q

GABA-A Receptor subtypes

A

a1 = Sedation + anticonvulsant
(+memory loss + addiction)

a2 = anxiolysis + muscle relaxant

a3 = (same as above)

a5 = muscle relaxant + (memory loss)

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