Drugs that Induce SLEEP Flashcards
1
Q
Awake promoting neurochemicals
6
A
ACh
NE
DA
His
5HT
OR
2
Q
Sleep promoting neurochemicals
5
A
GABA
Adenosine
PGD2
Cytokines
Galanin
3
Q
Pharmacology behind drugs used in sleep disorders
4 ways
A
- Enhance that activity of the VLPO
- Supress the activity of acendinf arousal
- Enhance circadian drive to sleep
- Work on the endocannabinoid system
4
Q
SUVOREXANT
A
OX1,OX2 Receptor Antagonist
5
Q
GABA-A Receptor subtypes
A
a1 = Sedation + anticonvulsant
(+memory loss + addiction)
a2 = anxiolysis + muscle relaxant
a3 = (same as above)
a5 = muscle relaxant + (memory loss)