Neuropharmacology Of Antipsychotics & AE Flashcards
4 dopaminergic pathways
- Nigrostriatal pathway
- Mesolimbic pathway
- Mesocortical pathway
- Tuberinfundibular pathway
Nigrostriatal pathway
Substantial nigra»_space; basal ganglia
MOVEMENT
Mesolimbic pathway
Ventral tegmental area (VTA)»_space; Nucleus accumbens
PLEASURE & REWARD
Mesocortical pathway
Ventral Tegmental Area (VTA)»_space; Prefrontal cortex
COGNITION
MEMORY
DECISION MAKING
Tuberoinfundibular pathway
Hypothalamus
INHIBITS PROLACTIN
DA released into portal circulation that connects to pituitary gland
Which region of brain gets you
Positive symptoms
Of schizophrenia
Over-activity of DA neurons in
MESOLIMBIC PATHWAY
(pleasure and reward)
Which part of brain gets you NEGATIVE SYMPTOMS of schizophrenia
MESOCORTICAL pathway
Cognition
Which pathway is responsible for antipsychotic effect of antipsychotic drugs
Antagonism of postsynaptic DA receptors in
MESOLIMBIC PATHWAY
The antagonism of DA (by antipsychotics) in which pathway causes EPSE??
Antagonism in the NIGROSTRIATAL pathway (movement)
Why do we use anti cholinergics to DECREASE EPSE ?
After antagonism of DA = get increase levels of Ach (at basal ganglia).
The decrease of DA and increase of Ach are responsible for EPSE
Effect of antipsychotics on the MESOCORITICAL pathway?
Cognitive side effects and emotional blunting
Effects of antipsychotics on the tuberoinfundibular pathway?
Increase prolactin
What receptors do conventional antipsychotics target? (Other than dopamine)
- Antagonise MUSCARINIC CHOLINERGIC receptors (M1)
- Antagonise HISTAMINERGIC receptors (H1)
- Antagonise ADRENERGIC Receptors
How to decrease POSITIVE symptoms
D2 antagonism in mesolimbic pathway
How to decrease negative symptoms
Enhanced DA release and 5HT2a antagonism in MESOCORTICAL pathway
