RNAV: Rhabdoviridae

Question 1

What is the subfamily/group of Rabies virus?

Answer 1

Lyssavirus

Question 2

What is the important member of the Lyssavirus group?

Answer 2

Rabies virus

Question 3

How is the Rabies virus transmitted?

Answer 3

Animal bite, Aerosolized transmission

Question 4

What laboratory procedures are used to diagnose Rabies virus infections?

Answer 4

Histopathology

Question 5

What is a key histopathological finding in Rabies virus infection?

Answer 5

Negri bodies in neurons

Question 6

What are the distinguishing characteristics of the Rabies virus?

Answer 6

Bullet-shaped, Enveloped

Question 7

What is the size and shape of the Rabies virus?

Answer 7

180x75 nm, Helical

Question 8

What is the gold standard test for detecting rabies virus antigens in brain tissue?

Answer 8

Direct Fluorescent Antibody (DFA) Test

Question 9

What sample types are used for RT-PCR in rabies diagnosis?

Answer 9

Saliva, Cerebrospinal fluid (CSF), Skin biopsy

Question 10

What histopathological finding is characteristic of rabies virus infection?

Answer 10

Negri bodies in neurons

Question 11

Where are Negri bodies commonly found in the brain?

Answer 11

Hippocampus and Purkinje cells

Question 12

What is the preferred specimen for postmortem rabies diagnosis?

Answer 12

Brain tissue

Question 13

Which laboratory method is used to test saliva for rabies?

Answer 13

Reverse Transcription Polymerase Chain Reaction (RT-PCR)

Question 14

What is the significance of a neck skin biopsy in rabies diagnosis?

Answer 14

Detects rabies antigen in peripheral nerves