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Mycology and Virology > DNAV: Herpesviridae > Flashcards

DNAV: Herpesviridae Flashcards

1
Q

What are the viruses found in the herpesviridae family?

A

Herpes Simplex 1 and 2
Varicella-Zoster
Epstein-Barr
Cytomegalovirus
Human Herpesvirus 6, 7, and 8

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2
Q

Which laboratory techniques can detect viral antigens of Herpes Simplex Virus 1?

A

Immunofluorescence or Immunoperoxidase

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3
Q

Which molecular method is commonly used to detect Herpes Simplex Virus 1 DNA?

A

Polymerase Chain Reaction

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4
Q

Which cell lines are commonly used for Herpes Simplex Virus 1 culture?

A

HeLa, fibroblasts, rabbit kidney cells

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5
Q

Which direct examination methods can identify Herpes Simplex Virus 1?

A

Pap smear or electron microscopy

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6
Q

What type of capsid does Herpes Simplex Virus 1 have?

A

Icosahedral

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7
Q

Where does Herpes Simplex Virus 1 establish latency?

A

Trigeminal ganglia

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8
Q

Which cytopathic effects are characteristic of Herpes Simplex Virus 1?

A

Multinucleated giant cells and intranuclear inclusions

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9
Q

What is the common name for an oral infection caused by Herpes Simplex Virus 1?

A

Cold sores

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10
Q

Which eye infection is associated with Herpes Simplex Virus 1?

A

Herpetic keratitis

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11
Q

What differentiates Herpes Simplex Virus 2 from Herpes Simplex Virus 1 in molecular testing?

A

Specific DNA primers or probes

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12
Q

What is the primary anatomical tropism of Herpes Simplex Virus 2?

A

Genital region

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13
Q

Which type of cancer is associated with Herpes Simplex Virus 2?

A

Cervical carcinoma

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14
Q

Which neurological disease can be caused by Herpes Simplex Virus 2?

A

Sporadic encephalitis

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15
Q

Which neonatal condition is caused by Herpes Simplex Virus 2?

A

Neonatal HSV infections

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16
Q

Which cytology findings are characteristic of Varicella-Zoster Virus?

A

Intranuclear inclusions and multinucleated giant cells

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17
Q

Which laboratory tests detect antibodies against Varicella-Zoster Virus?

A

Serological tests

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18
Q

Which molecular test is commonly used for Varicella-Zoster Virus detection?

A

Polymerase Chain Reaction

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19
Q

Which type of vaccine is available for Varicella-Zoster Virus?

A

Live attenuated vaccine

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20
Q

What is the characteristic rash seen in Varicella-Zoster Virus infection?

A

Dewdrop-on-rose-petal lesions

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21
Q

Which disease results from reactivation of Varicella-Zoster Virus?

A

Shingles (Herpes zoster)

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22
Q

What is the primary disease caused by initial infection with Varicella-Zoster Virus?

A

Chickenpox (Varicella)

23
Q

Which molecular technique is commonly used to detect Epstein-Barr Virus?

A

Polymerase Chain Reaction

24
Q

Which test detects heterophile antibodies in Epstein-Barr Virus infections?

A

Monospot test

25
Q

What type of envelope does Epstein-Barr Virus have?

26
Q

Which lymphoma is strongly associated with Epstein-Barr Virus?

A

Burkitt’s lymphoma

27
Q

Which type of carcinoma is linked to Epstein-Barr Virus infection?

A

Nasopharyngeal carcinoma

28
Q

Which disease caused by Epstein-Barr Virus is also known as the kissing disease?

A

Infectious mononucleosis

29
Q

Which direct cytology finding is characteristic of Cytomegalovirus infection?

A

Owl-eye inclusions

30
Q

Which molecular test is commonly used for Cytomegalovirus detection?

A

Polymerase Chain Reaction

31
Q

Which antigen detection methods are used for Cytomegalovirus?

A

Immunofluorescence and enzyme-linked immunoassay

32
Q

Which type of cell culture is used for Cytomegalovirus isolation?

A

Fibroblasts

33
Q

What is the structural classification of Cytomegalovirus?

34
Q

Which herpesvirus is the largest in size?

A

Cytomegalovirus

35
Q

Which type of infection is commonly caused by congenital Cytomegalovirus transmission?

A

Congenital infections

36
Q

Which mononucleosis-like illness can be caused by Cytomegalovirus?

A

CMV mononucleosis

37
Q

Which patient group is at high risk for Cytomegalovirus complications?

A

Transplant patients

38
Q

Which molecular method is used to detect Human Herpesvirus 6?

A

Polymerase Chain Reaction

39
Q

What is the envelope status of Human Herpesvirus 6?

40
Q

Which childhood disease is caused by Human Herpesvirus 6?

A

Roseola (Exanthem subitum)

41
Q

Which neurological complication is associated with Human Herpesvirus 6 infection in children?

A

Febrile seizures

42
Q

What type of genetic material does Human Herpesvirus 6 contain?

A

Double-stranded DNA

43
Q

Which immune cells are primarily infected by Human Herpesvirus 6?

44
Q

Which childhood disease is commonly caused by Human Herpesvirus 6 and 7?

45
Q

Which mononucleosis-like illness can be caused by Human Herpesvirus 6?

A

Some cases of mononucleosis

46
Q

Which laboratory method is used for visualizing Human Herpesvirus 6 and 7 particles?

A

Electron microscopy

47
Q

Which human herpesvirus is most similar to Human Herpesvirus 6?

A

Human Herpesvirus 7

48
Q

What is the envelope status of Human Herpesvirus 8?

49
Q

Which cell surface receptor does Human Herpesvirus 8 use for entry?

50
Q

Which cancer is strongly associated with Human Herpesvirus 8 infection?

A

Kaposi’s sarcoma

51
Q

Which group of patients is at high risk for Human Herpesvirus 8-associated Kaposi’s sarcoma?

A

AIDS patients

52
Q

Which molecular technique is commonly used to detect Human Herpesvirus 8?

A

Polymerase Chain Reaction

53
Q

Which type of biopsy is used for detecting Human Herpesvirus 8 in Kaposi’s sarcoma lesions?

A

Kaposi’s sarcoma biopsy

Mycology and Virology (21 decks)

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