RNA Viruse: Orthomyxoviruses And Paramyxoviruses

Question 1

Genome of Orthomyxoviridae

Answer 1

Spherical
-ssRNA genome : appears as 8 separate molecules
HA-hemagglutinin and NA-neuraminidase protein **

Question 2

Classification of Orthomyxoviridae

Answer 2

Influenza A and B viruses
Influenza C virus
Tick-borne Orthomyxoviruses

Question 3

Influenza A and B

Answer 3

Type A does not share ag with Influenza B
Many sub-types
Differ in HA or NA protein
14 subtypes of HA
9 subtypes of NA

Question 4

Type specific antigens for Influenza A,B

Answer 4

Nucleoprotein
Matrix protein

Question 5

Hemagglutinin

Answer 5

Sites for attachment to infect host cells (Salic acid)
H1-H15

Question 6

Neuraminidase

Answer 6

Remove neuraminic acid from mucin and release from cell
N1-N9

Question 7

Antigenic shifts of which protein results in pandemics

Answer 7

Haemagglutinin

Question 8

Antigenic drifts in which proteins result in epidemics

Answer 8

Hemagglutinin
Neuraminidase

Question 9

Forming new subtype

Answer 9

Antigenic shift

Question 10

Forming new strain of virus

Answer 10

Antigenic drift

Question 11

Large change in nucleotides of RNA

Answer 11

Antigenic shift

Question 12

Small mutation of RNA

Answer 12

Antigenic drift

Question 13

Occurs as a result of genome reassortment between difference subtypes

Answer 13

Antigenic shift

Question 14

Occurs as a result of the accumulation of point mutations in the gene

Answer 14

Antigenic drift

Question 15

An antigenic change can alter antigenic sites on the molecule such that a vision can escape recognition by the hots immune system

Answer 15

Antigenic drift

Question 16

An antigenic change which results in severe alternation in HA or NA subtypes

Answer 16

Antigenic shift

Question 17

Large and sudden mutation

Answer 17

Antigenic shift

Question 18

Random and spontaneous mutation

Answer 18

Antigenic drift

Question 19

Genome of Influenza C

Answer 19

Distinct genus
7 RNA segments

Question 20

Single envelope glycoprotein in Influenza C function as HA

Answer 20

HEF—> fusion protein and esterase

Question 21

Mutation capacity of HA,NA influence

Answer 21

The virulence

Question 22

Replication of Orthomyxoviridae

Answer 22

In ciliated columnar epi of respiratory tract

Question 23

In Orthomyxoviridae inflammatory response produced by CD4 T cells contributes to

Answer 23

Pneumonia

Question 24

Clinical features of Orthomyxoviridae

Answer 24

Abrupt onset of fever, sore throat, nonproductive cough, myalgia, headache, malaise
Uncomplicated syndrome: 3-7 days
Wakness and cough: 2-3 weeks

Question 25

Transmission of Orthomyxoviridae

Answer 25

Aerosols

Question 26

Lab diagnosis of Orthomyxoviridae

Answer 26

Clinical diagnosis
PCR
Cell culture
EIA
Molecular methods
Immunofluorescence
Serology

Question 27

Management of Orthomyxoviridae

Answer 27

Amantidine
Rimantidine
Ribavirin
NA inhibitors

Question 28

Against which type of Influenza there are vaccines

Answer 28

A and B

Question 29

Genome of Paramyxoviruses

Answer 29

Very fragile lipid envelope
Non-segmented linear genome
Spherical,helical symmetry but pleomorphic

Question 30

Which virus has croup agent

Answer 30

Parainfluenza virus

Question 31

Genome of Parainfluenza virus

Answer 31

SsRNA
Enveloped
Pleomorphic
5 stereotypes : 1,2,3,4a,4b

Question 32

Classification of Paramyxovirus

Answer 32

Measles
Mumps
Respiratory Syncytial
Parainfluenza

Question 33

Genome of Respiratory Syncytial virus

Answer 33

SsRNA enveloped

Question 34

Respiratory syncytial virus causes

Answer 34

Lower respiratory tract illness in infants and young children

Question 35

Mumps causes

Answer 35

Painful enlargement of the salivary glands — parotid glands

Question 36

Which Paramyxovirus has vaccine

Answer 36

Mumps
Measles

Question 37

Which virus causes Obliteration of the angle of the jaw

Answer 37

Mumps virus

Question 38

Transmission of measles

Answer 38

Direct droplet contact

Question 39

Koplik spots belongs to

Answer 39

Measles virus