DNA Viruses Adenoviruses, Parvoviruses, Papaviruses And Poxiviruses

Question 1

Which viruses are the Poxviruses

Answer 1

Mollusicipoxvirus
Parapoxvirus
Orthopoxvirus — Cowpox,Monkeypox and Variola virus

Question 2

Which virus is the largest virus

Answer 2

Poxviruses

Question 3

Features of genome of Poxviruses

Answer 3

Brick shaped with a complex morphology.
Large double stranded, linear DNA
Enveloped
Core( viral DNA and protein)
Core membrane

Question 4

Replication of Poxviruses

Answer 4

**Entire multiplication cycle takes place within the host cell cytoplasm.
Viral DNA then replicates in electron-dense cytoplasmic inclusions referred to as factories.

Question 5

Pathogenesis of Poxviruses

Answer 5

Smallpox replicates in the upper respiratory tract
Dissemination occurs via lymphatic and cell-associated viremic spread.
Molluscum contagiosum and the other poxviruses requires direct contact with lesions.

Question 6

Which poxviruses are strictly human viruses

Answer 6

Smallpox and molluscum contagiousum

Question 7

Which viruses are subgroup of Poxviruses

Answer 7

Molluscipoxvirus ( Molluscum contagiosum virus)
Parapoxvirus ( Orf virus)
Orthopoxvirus ( Vaccinia virus)
Cowpox virus
Monkeypox virus
Variola virus ( causes Smallpox)

Question 8

Clinical features of Smallpox

Answer 8

Incubation: 5-17 days
High fever, fatigue, severe headache, and malaise, vesicular rash in the mouth and on the body.
Vomiting, diarrhea and excessive bleeding can be seen in immune suppressed patients
Exclusive human host range

Question 9

Which virus’s eradication was the first disease to be controlled by immunization

Answer 9

Smallpox

Question 10

Features of ORF virus

Answer 10

Human infection occurs with the direct contact with the animal
Causes modular formation on the surface of the point of the contact

Question 11

Features of Monkeypox

Answer 11

Can spread to anyone through close, personal often skin-to-skin contact
Rash that may be close to genitals or anus can be on the hands etc
Rash will go through several stages, including scabs, before healing.

Question 12

Features of the Molluscum Contagiosum

Answer 12

Most common on the trunk, genitalia and proximal extremities
More common in children
Incidences Increases in sexually active individuals

Question 13

Which viruses are in the family of Papovaviruses

Answer 13

2 Oncogenic DNA viruses
Papillomaviruses
Polyomaviruses
Simian Vacuolating Agent

Question 14

Features of the Papovaviruses

Answer 14

Small DNA tumor viruses
Infect vertebrates with species-specificity
Etiologies agents of benign diseases and malignancy

Question 15

Human Polyomavirus JC

Answer 15

Cytolytic destruction of oligodendrocytes
Associate with brain tumors, medulloblastoma
Asymptomatic
More common due to HIV/AIDS

Question 16

**PAPİLLOMAVİRUS causes?

Answer 16

Skin Warts
-flat warts, plantar warts

Genital Warts : transmitted by sexual intercourse

GENITAL CANCERS AND PAPİLLOMAVIRUS IS DEFİNETLY ASSOCIATED

Question 17

What is the characteristic feature of Papillomavirus

Answer 17

Warts

Question 18

How is the pathogenesis of Papillomavirus

Answer 18

1- Inoculation of epithelium (hand,foot,throat or cervix)
2- Local multiplication — WART which can have a latency

Question 19

What are the prevention techniques of Papillomavirus

Answer 19

1- Prophylactic HPV Vaccination
2- Cervical screening and treatment

Question 20

General concepts of Parvovirus

Answer 20

Group of small DNA viruses
Parvovirus B19 causes Fifth Disease: mild rash illness
Spread: via the respiratory route or blood-borne transmission
Pathogenesis: slapped-cheek appearance

Question 21

Adenoviruse causes?

Answer 21

Wide range of illnesses including : common cold or flu-like symptoms, fever , sore throat, pink eye, acute bronchitis, pneumonia, diarrhea, acute gastroenteritis, vomiting, nausea

Question 22

How is the genome of Adenoviruses

Answer 22

Non-enveloped
Linear large ds DNA
40 serotypes

12 antenna-like fiber projections

Question 23

Adenoviruses effect which cells

Answer 23

Both nondividing and dividing cells

Question 24

Which virus is the most producing respiratory infections in humans

Answer 24

Adenoviruses

Question 25

Why Adenoviruses are so common

Answer 25

Bc it is easily transmissible (swimming pools)

Question 26

Transmission of Adnoviruses

Answer 26

Specific epidemic serotypes
- Pharyngoconjunctival fever = Ad3,Ad7
-Hemorrhagic keratoconjunctivitis = Ad8,Ad37
-Acute respiratory disease = Ad4,Ad7