DNA Viruses Adenoviruses, Parvoviruses, Papaviruses And Poxiviruses Flashcards
Which viruses are the Poxviruses
Mollusicipoxvirus
Parapoxvirus
Orthopoxvirus — Cowpox,Monkeypox and Variola virus
Which virus is the largest virus
Poxviruses
Features of genome of Poxviruses
Brick shaped with a complex morphology.
Large double stranded, linear DNA
Enveloped
Core( viral DNA and protein)
Core membrane
Replication of Poxviruses
**Entire multiplication cycle takes place within the host cell cytoplasm.
Viral DNA then replicates in electron-dense cytoplasmic inclusions referred to as factories.
Pathogenesis of Poxviruses
Smallpox replicates in the upper respiratory tract
Dissemination occurs via lymphatic and cell-associated viremic spread.
Molluscum contagiosum and the other poxviruses requires direct contact with lesions.
Which poxviruses are strictly human viruses
Smallpox and molluscum contagiousum
Which viruses are subgroup of Poxviruses
Molluscipoxvirus ( Molluscum contagiosum virus)
Parapoxvirus ( Orf virus)
Orthopoxvirus ( Vaccinia virus)
Cowpox virus
Monkeypox virus
Variola virus ( causes Smallpox)
Clinical features of Smallpox
Incubation: 5-17 days
High fever, fatigue, severe headache, and malaise, vesicular rash in the mouth and on the body.
Vomiting, diarrhea and excessive bleeding can be seen in immune suppressed patients
Exclusive human host range
Which virus’s eradication was the first disease to be controlled by immunization
Smallpox
Features of ORF virus
Human infection occurs with the direct contact with the animal
Causes modular formation on the surface of the point of the contact
Features of Monkeypox
Can spread to anyone through close, personal often skin-to-skin contact
Rash that may be close to genitals or anus can be on the hands etc
Rash will go through several stages, including scabs, before healing.
Features of the Molluscum Contagiosum
Most common on the trunk, genitalia and proximal extremities
More common in children
Incidences Increases in sexually active individuals
Which viruses are in the family of Papovaviruses
2 Oncogenic DNA viruses
Papillomaviruses
Polyomaviruses
Simian Vacuolating Agent
Features of the Papovaviruses
Small DNA tumor viruses
Infect vertebrates with species-specificity
Etiologies agents of benign diseases and malignancy
Human Polyomavirus JC
Cytolytic destruction of oligodendrocytes
Associate with brain tumors, medulloblastoma
Asymptomatic
More common due to HIV/AIDS
**PAPİLLOMAVİRUS causes?
Skin Warts
-flat warts, plantar warts
Genital Warts : transmitted by sexual intercourse
GENITAL CANCERS AND PAPİLLOMAVIRUS IS DEFİNETLY ASSOCIATED
What is the characteristic feature of Papillomavirus
Warts
How is the pathogenesis of Papillomavirus
1- Inoculation of epithelium (hand,foot,throat or cervix)
2- Local multiplication — WART which can have a latency
What are the prevention techniques of Papillomavirus
1- Prophylactic HPV Vaccination
2- Cervical screening and treatment
General concepts of Parvovirus
Group of small DNA viruses
Parvovirus B19 causes Fifth Disease: mild rash illness
Spread: via the respiratory route or blood-borne transmission
Pathogenesis: slapped-cheek appearance
Adenoviruse causes?
Wide range of illnesses including : common cold or flu-like symptoms, fever , sore throat, pink eye, acute bronchitis, pneumonia, diarrhea, acute gastroenteritis, vomiting, nausea
How is the genome of Adenoviruses
Non-enveloped
Linear large ds DNA
40 serotypes
12 antenna-like fiber projections
Adenoviruses effect which cells
Both nondividing and dividing cells
Which virus is the most producing respiratory infections in humans
Adenoviruses
Why Adenoviruses are so common
Bc it is easily transmissible (swimming pools)
Transmission of Adnoviruses
Specific epidemic serotypes
- Pharyngoconjunctival fever = Ad3,Ad7
-Hemorrhagic keratoconjunctivitis = Ad8,Ad37
-Acute respiratory disease = Ad4,Ad7
