RNA Virus Flashcards
What are the types of Picornaviruses
Enterovirus
Rhinovirus
Hepatovirus
Cardiovirus
Aphthovirus
Hepatovirus example
Hepatitis A virus
Cardiovirus example
Encephalomyocarditis virus
Human porechovirus
Example of Apthovirus
Foot-hand-mouth virus
How is the genome of Picornaviruses
+ ss RNA — able to act as mRNA when it enters to cell
What is the major receptor for Poliovirus
CD155
What are the examples of Enterovirus
Poliovirus
Human Enterovirus A,E
Coxockieviruses A,B
Echoviruses
Examples of Rhinovirus
Human rhinovirus A,B
Whic family of viruses have Lytic Infection
Picornaviruses
Non-Enterovirus diseases
Coxcakievirus A
Coxcakievirus B
Echoviruses
Enterovirus 70
Enterovirus 71
Features of Enteroviruses
PH range 3-10
Small intestine is the major invasion site
Resistant to acidic pH
Replicate best at=37 Celsius
Features of Rhinovirus
Ph= 6-8
Sensitive to acidic pH
Optimally replicate at = 33 Celsius
Which Picornavirus cannot reach to stomach
Rhinovirus bc it is sensitive to the acidic pH
How is the transmission of Enteroviruses
Ingestion of fecally infected material
Respiratory route
Where does Enterovirus replicate at
Susceptible tissues of phayrinx or gut
Lymphoid tissue of the small intestine
Reticuloendothelial tissue
Where does Enterovirus gives rise to minor and major viremia
Minor= regional lymph node
Major= Reticuloendothelial tissue
What is Poliomyelitis
Caused by Poliovirus( Enterovirus— Picornavirus)
3 stereotypes = PV1,PV2,PV3
Minimal heterotypic immunity
1 in 200 infections leads to irreversible paralysis
Vaccines = IPV, OPV
What does Coxcakievirus A causes
Herpangina
Hem. Conjunctiva A24
Hand foot mouth disease
What does Coxcakievirus B causes?
Myocarditis
Pericarditis
What does Echovirus causes
Aseptic meningitis
What does Enterovirus 70 causes
Hem. Conjunctivitis
What does Enterovirus 71 causes
CNS disease
Hand foot mouth disease
Features of Rhabdoviruses
Neurotropic virus
Enveloped
SsRNA
How is the rabies best spreaded
When the bite of the infected animal is deep enough to allow the virus to reach the deep skeletal muscle.
How is the transmission of Rhinovirus
Aerosols
Direct contact
How is the genome of Rhabdoviruses
GpG
Bullet-shaped
Enveloped
M protein
N protein
L protein
P protein
Helical Nucleocapsid
How is the Initial infection of Rhabdoviruses
Replication in muscle or subepi
Spreads to nerves by binding to Ach receptors
What are the stages of Classical Rabies
Prodromal stage=fever,headache,malaise..
Sensory excitation stage=hyperactivity,hallucinations..
Coma and paralysis phase=paralysis and respiratory problems, death
What is the post-exposure vaccine to Rabies
Human Diploid Cell Vaccination
How is the genome of Reovirus
Non enveloped
DsRNA-segmented
Which virus is the agents of Viral Gastroentritis in children
Rotavirus
Features of Rotavirus
Very stable
Remain infective
Resistant to acidic pH
11 gene segments
Three concentric capsid
Which viruses are in the family of Reovirus
Rotavirus
Orthoreovirus
Coltivirus
Orbivirus
What are the gene segments of Rotavirus
VP7 — G glycoprotein —— Genotypes: G1P,G2P,G3P,G4P,G9P
VP4— P protease sensitive ——Serogroups: A,B,C,D,E,F (inner core structural proteins)
