Herpes Viruses Flashcards
HHV-1
Latency:?
Target:?
Herpes simple virus 1
Neurotrophic
Alpha herpesvirus
Seen usually in upper side of the body
Latency: sensory-sacral ganglia
Target: mucoepithelia
HHV-2
Causes:?
Target:?
Latency:?
Herpes simplex virus-2
Neurotrophic
Alpha-herpesvirus
Causes:Genital infections
Target: mucoepi
Latency: sensory-sacral ganglia
HHV-3
Causes:?
Target:?
Latency:?
Varicella-Zoster virus
VZV
Neurotrophic
Alpha-herpesvirus
Causes:chickenpox and shingles
Target: much epithelia
Latency: dorsal root or cranial nerve ganglia
Alpha-herpesvirus özellikleri?
Wide range host
Short replication cycle
Rapid growth
Latent infection in sensory and cranial ganglia
Transmitted by: direct contact,sexual,perinatal also for VZV: Aerosol
HHV-4?
Causes:?
Target:?
Latency:?
Epstein-Barr Virus
EBV
Gamma-herpesvirus
Causes: kissing disease, Malignancies—> Endemic Burkitts Lymphoma, B cell Lymphoma, Nasopharyngeal carcinoma
Target: B lymphocytes, M cells, Nasopharyngeal epi. Cells
Latency: B cells (?)
HHV-5?
Target:?
Latency:?
Causes:?
Cytomegalovirus
CMV
Beta-herpesvirus
Target: Monocytes
Causes: genital infection
Latency: Monocytes
HHV-6,7?
Target:?
Latency:?
Causes:?
Human herpes virus 6,7
Beta-herpesvirus
Target: T cells, NK
Latency: T cells, NK
Causes:encephalitis, autoimmune diseases, reactivation in solid organ transplants, Hodgkin disease (?)
Beta-herpesvirus özellikleri?
Limited host range
Long replication
Slow growth
LI in lymphocytes
Enlargement of infected cell
Transmission: Blood products, Sexual, Perianal.
HHV-8?
Target:?
Latency:?
Causes:?
Kaposi Sarcoma Related Virus
KSRV
Gamma-herpesvirus
Target: B,T cells
Latency: Monocytes, dendritic cells, B cells
Causes: Kaposi’s sarcoma, B cell lymphoma, Castleman’s disease
Gamma-herpesvirus özellikleri?
LI in early infection
LI in lymphocytes
Transmission: Saliva, perinatal.
