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Microbiology > Coronavirus, Falvivirus, Calicivirus > Flashcards

Coronavirus, Falvivirus, Calicivirus Flashcards

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Biology 101 flashcards
1
Q

Structure of the Coronavirus

A

Enveloped
+ ss RNA — can act as mRNA and goes to ribosome directly
Helical symmetry
Replicate in host cell cytoplasm
Higher replication error rate
Big size
High frequency of new viral subtypes

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2
Q

Proteins of Coronavirus

A

Spike protein
Membrane protein — integral membrane protein
Some have Hemagglutinin esterase — receptor binding

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3
Q

Spike protein of Coronavirus

A

Receptor binding activity
Membrane fusion activity
Major ag for neutralizing ab

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4
Q

Human coronaviruses

A

Alpha coronaviruses
Beta coronaviruses — common cold

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5
Q

2 serotypes of Alpha coronaviruses

A

229E
NL63

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6
Q

Coronaviruses that can infect both humans and animals

A

SARS-CoV
MERS-CoV
SARS-CoV-2

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7
Q

Similarity between SARS-CoV and SARS-CoV-2

A

Genuses are same : Clade 1, lineage B

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8
Q

Which receptor does SARS-CoV uses

A

ACE-2

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9
Q

Which receptor does MERS-CoV uses

A

DPP4—> Dipeptidyl peptidase 4

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10
Q

Which receptor does SARS-CoV-2 uses

A

ACE-2

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11
Q

Among coronaviruses which one have the highest mortality rate

A

MERS

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12
Q

Among Coronaviruses which one is the most infective one

A

SARS has the highest R0

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13
Q

Characteristic lab finding of COVID

A

Lymphopenia
Elevated Lactate Dehydrogenase

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14
Q

Main variant of COVID

A

Omicron

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15
Q

Diagnosis of SARS-CoV, MERS-CoV and SARS-CoV-2

A

Rt-PCR test
Serology

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16
Q

Antiviral drug for SARS-CoV

A

Remdesivir

17
Q

Which coronavirus have a vaccine

A

SARS-CoV-2

18
Q

Properties of Calicivirus

A

Small virion
Positive sense
Ss RNA
Icosahedral capsid symmetry
* Not cultivated in vitro

19
Q

Human agent of Calicivirus

A

Norovirus

20
Q

Species of Norovirus

A

Norwalk virus

21
Q

Transmission of Norovirus

A

Extremely contagious
Very low ID50
Person to person contact
Contaminated water or food
Survives long on surfaces

22
Q

Norovirus causes

A

Diarrhea
Vomiting
Non bacterial gastroenteritis outbreaks
* Stomach flu

23
Q

Pathogenesis of Norovirus

A

Usually produces incomplete and temporary immunity
No vaccine bc of this

24
Q

Arenavirus causes

A

Rodent-transmitted disease in humans

25
Q

Properties of Arenavirus

A

Spherical shape
Linear or circular - sense ssRNA
Enveloped
Replicates in host cell cytoplasm

26
Q

Reservoir of Arenavirus

A

Rodents

27
Q

Transmission of Arenavirus

A

Transmitted by rodent urine/ feces
contaminated food/ water / aerosols

28
Q

Which Arenavirus is the only one that exist in both new world and old world

A

Lymphocytic choriomeningitis

29
Q

Arenavirus-LCM virus properties

A

Flu-like febrile illness
Cause meningitis
** Large numbers of lymphocytes in CSF —> characteristic
Vertical transmission to fetus

30
Q

Arenavirus-Lassa fever

A

Lassavirus
*Person to person transmission
Asymptomatic
Endo cell damage
Platelet dysfunction —> bleeding can not stop
Suppressed cardiac function

31
Q

Diagnosis of Arenaviruses

A

ELISA
IgM and IgG
RT-PCR

32
Q

Treatment of Arenavirus

A

Supportive therapy
Ribavirin
No vaccine

33
Q

Filovirus causes

A

Hemorrhagic fever in humans and nonhuman primates

34
Q

Two members of Filovirus

A

Marburgvirus and Ebolavirus

35
Q

Transmission of Filoviruses

A

Transmission to human is unknown
Transmitted from patient to a close contact by infective body fluids

36
Q

Properties of Marburgvirus and Ebolavirus

A

Filamentous
Enveloped
Helical capsid
Negative-sense
Ss RNA
Replicates in the host cell cytoplasm
Produces a lot of virions

37
Q

Marburgvirus and Ebolavirus causes

A

Tissue necrosis in organs
Endo cell/platelet dysfunction
Whole body is effected bc it effects cell vessels
Internal and external bleeding

38
Q

Diagnosis of Marburgvirus and Ebolavirus

A

Detection of IgM or viral ag

39
Q

Treatment of Ebola

A

Supportive care
No virus specific drug

Microbiology (22 decks)

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