Rheumatoid Arthritis Drugs Flashcards
what is Rheumatoid Arthritis
immunologic disease that causes systemic effects which shortens life and joint disease that reduces mobility and quality of life
what is RA driven by
activated T cells given rise to IL-1 and TNF
classes of drugs used to treat RA
NSAIDs
Glucocorticoids
DMARDs
of all the classes, which ones reduces or prevents joint damage/ stop progression of the disease
DMARDs (disease modifying antirheumatic drugs)
NSAIDs and glucocorticoids treat symptoms and improve quality of life but do not slow down progression of RA
first DMARD prescribed whether it is mild, moderate, or severe in RA
Methotrexate
what are the non biological DMARDs
CC HALMS
Cyclosporine
Cyclophosphamide
Hydroxychloroquine Azathioprine Leflunomide Methotrexate Sulfasalazine
what are the biological DMARDs
Anti-TNF-α: Adalimumab, Etanercept, Infliximab
Rituximab
Abatacept
Anakinra
patients who do not respond to methotrexate alone should be given what in adjuvant
Leflunomide
least toxic of all DMARDs but least effective as a monotherapy
Hydroxychloroquine
side effect of Cyclosporine
GOHN
Gum Hyperplasia
Osteoporosis
Hirsutism
NEPHROTOXICITY
situation is cyclophosphamide reserved for
severe RA with systemic features like vasculitis
name the Anti-TNF-α drugs used to treat RA again
Adalimumab
Etanercept
Infliximab
which of the treatments of RA act more quickly
the Anti-TNF-α act more quickly than the non biological DMARDs
what are NSAIDs used for in RA
anti inflammatory actions
bridge drugs for relief of symptoms
first line biological agent for RA
Anti-TNF-α: Adalimumab, Etanercept, Infliximab
