Autacoids II Flashcards
main source of eicosanoids
arachidonic acid
difference between COX (cyclo-oxygenase) and LOX (lipoxygenase)
COX initiates synthesis of prostaglandins, prostacyclins, and thromboxanes
LOX initiates synthesis of leukotrienes and other compounds
name the eicosanoids
PALM CD
prostacyclin, alprostadil, latanoprost, misoprostol, carboprost tromethamine, dinoprostone
eicosanoid used to ripen cervix at or near term
dinoprostone (PGE2) and misoprostol (PGE1)
for management of post partum hemorrhage
misoprostol and carboprost tromethamine
used as abortifacient in second trimester of pregnancy
dinoprostone and carboprost tromethamine
what is misoprostol used for
- ripen cervix at term
- post partum hemorrhage
- prevention of peptic ulcers in pts who take high doses of NSAIDs
- as an abortifacient if used in combination with mifepristone or methotrexate
what is alprostadil used for
- maintain patency of ductus arteriosus in infants with transposition of great vessels until surgery is done
- treatment of impotence
what is used for pulmonary hypertension and dialysis
prostacyclins (and epoprostenol)
latanaprost used for
glaucoma
what are the eicosanoid antagonist
zileuton, zafirlukast, montelukast
how do these said eicosanoid antagonist work
- zileuton inhibits 5-LOX hence preventing leukotriene synthesis
helping with effects of asthma like bronchoconstriction etc
- zafirlukast and montelukast inhibit binding of LTD4 binding to its target thereby preventing its action
what does glucocorticoids inhibit
- PLA2 hence inhibiting release of arachidonic acid
- synthesis of COX-2
what do NSAIDs inhibit and what does it lead to
inhibit COX
leads to its effect as an anti-pyretic (anti-fever), analgesic (anti-pain), and anti inflammatory activities
