Anticancer Drugs III Flashcards

1
Q

what are the classes of signal transduction inhibitors

A

BRAPE

BCR-ABL and C-KIT inhibitor
RAS/MAP Kinase pathway inhibitor
Angiogenesis Inhibitor
Proteasome Inhibitor
EGFR (ErbB1) and HER2/neu (ErbB2) inhibitor
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2
Q

inhibitor of EGFR/ErbB1 tyrosine kinase

A

Gefitinib

Erlotinib

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3
Q

monoclonal antibody against EGFR/ErbB1

A

Cetuximab

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4
Q

monoclonal antibody against HER2/neu (ErbB2)

A

Trastuzumab

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5
Q

adverse effect of monocolonal antibody against HER2/neu (ErbB2) – name it

A

Trastuzumab

cardiotoxic

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6
Q

inhibitor of EGFR (ErbB1) and HER2/neu (ErbB2)

A

Lapatinib

GECTL

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7
Q

inhibitor of BCR-ABL and C-KIT

A

Imatinib

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8
Q

inhibitor of RAS/MAP kinase pathway

A

Sorafenib

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9
Q

name the proteasome inhibitor and mechanism

A

Bortezomib

induces growth inhibition and apoptosis of tumor cells

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10
Q

angiogenesis inhibitor and mechanism

A

Sunitinib

inhibits VGEFR-1, VGEFR-2, PDGFR

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11
Q

mechanism of Asparginase

A

hydrolyzes circulating L-asparagine to aspartic acid ammonia –> depleting tumor cells of asparagine needed for protein synthesis

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12
Q

mechanism of hydroxyurea

A

inhibits ribonucleotide reductase needed to form deoxyribonucleoside diphosphate from ribonucleoside diphosphate

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13
Q

mechanism of IFNalpha

A
  • stimulates natural killer cells to kill transformed cells

- increases expression of HLA molecules on tumor cells

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