Anticancer Drugs III Flashcards
what are the classes of signal transduction inhibitors
BRAPE
BCR-ABL and C-KIT inhibitor RAS/MAP Kinase pathway inhibitor Angiogenesis Inhibitor Proteasome Inhibitor EGFR (ErbB1) and HER2/neu (ErbB2) inhibitor
inhibitor of EGFR/ErbB1 tyrosine kinase
Gefitinib
Erlotinib
monoclonal antibody against EGFR/ErbB1
Cetuximab
monoclonal antibody against HER2/neu (ErbB2)
Trastuzumab
adverse effect of monocolonal antibody against HER2/neu (ErbB2) – name it
Trastuzumab
cardiotoxic
inhibitor of EGFR (ErbB1) and HER2/neu (ErbB2)
Lapatinib
GECTL
inhibitor of BCR-ABL and C-KIT
Imatinib
inhibitor of RAS/MAP kinase pathway
Sorafenib
name the proteasome inhibitor and mechanism
Bortezomib
induces growth inhibition and apoptosis of tumor cells
angiogenesis inhibitor and mechanism
Sunitinib
inhibits VGEFR-1, VGEFR-2, PDGFR
mechanism of Asparginase
hydrolyzes circulating L-asparagine to aspartic acid ammonia –> depleting tumor cells of asparagine needed for protein synthesis
mechanism of hydroxyurea
inhibits ribonucleotide reductase needed to form deoxyribonucleoside diphosphate from ribonucleoside diphosphate
mechanism of IFNalpha
- stimulates natural killer cells to kill transformed cells
- increases expression of HLA molecules on tumor cells