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Pharmacology > Bone Mineral Homeostasis II > Flashcards

Bone Mineral Homeostasis II Flashcards

1
Q

what is Cinecalcet

A

activates calcium sensing receptors in PTH cells –> decreased PTH synthesis and release

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2
Q

use of Cincecalcet

A

secondary hyperparathyroidism in chronic renal disease

hyperparathyroidism in patients with parathyroid carcinoma

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3
Q

AE of cincecalcet

A

Nausea

Hypocalcemia

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4
Q

Fluoride’s role in calcium homeostasis

A

chronic exposure –> new bone synthesis –> more dense but brittle

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5
Q

Gallium nitrate’s role in calcium homeostasis

A

inhibits bone resorption –> used in cancer related hypercalcemia

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6
Q

AE of Gallium nitrate

A

nephrotoxic

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7
Q

Miscellaneous affecting calcium homeostasis

A

FGPT

Fluoride
Gallium Nitrate
Plicamycin
Thiazides

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8
Q

drugs used for cancer related hypercalcemia

A

Gallium nitrate and Plicamycin

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9
Q

mechanism of Plicamycin (other name for it)

A

Mithracin

cytotoxic cancer drug

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10
Q

AE of plicamycin

A

TRH

Thrombocytopenia
Renal Toxicity
Hepatic Toxicity

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11
Q

drugs that cause osteoporosis

A

CHAAL

Corticosteroids
Heparin
Anastrozole
Alcohol
Lithium
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12
Q

Drugs that cause osteomalacia

A 
Phenytoin
Etridonate (used longer than 12 months)
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13
Q

mechanism of thiazides in calcium homeostasis

A

increases reuptake of calcium and decreases its excretion

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14
Q

uses of thiazides

A
  • hypertension in those with osteoporosis

- treats hypercalciuria or kidney stones

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15
Q

how do hypercalcemia patients present

A
  • stones (nephrolithiasis)
  • groans (abdominal pain)
  • bones (bone pain, myalgia, arthralgia, fracture)
  • thrones (sit on throne for polyuria)
  • psychiatric overtones (fatigue, depression, anxiety, sleep disturbances)
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16
Q

treatment of hypercalcemia

A

Furosemide (loop diuretic) and saline solution
Bisphosphonates (RAPE)
Calcitonin
Parathyroidectomy

17
Q

treatment of osteoporosis

A
  • Stop smoking, alcohol abuse, corticosteroid
  • HRT in post menopausal women
  • Calcium and Vit D supplements
  • Bisphosphonates
  • SERMs
  • Teriparatide

Pharmacology (79 decks)

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