Respiratory Pharmacology II Flashcards
what causes failure of asthma management
- lack of adherence to medication
- uncontrolled co-morbid conditions
- continued exposure to tobacco smoke, airborne pollutants, allergens, and irritants
what are the asthma medications for exacerbations (use mnemonic)
ASTHMA Albuterol, Pirbuterol, Terbutaline Steroids Theophylline Humidifier O2 Magnesium (severe exacerbation when other methods not working) Anticholinergics
at what point do you add antibiotics as an additional treatment for COPD
when FEV1/FVC ratio is below 49%
mnemonic for COPD ts
COPD
Corticosteroids
Oxygen
Prevention (cessation of smoking, infection control, pneumococcal and influenza vaccine)
Dilators (anticholinergics and beta 2 agonists)
what are the opioids that are used an antitussives (cough medication)
codeine
dextrometorphan (synthetic codeine)
how do opiates work to reduce cough
decrease CNS cough center’s sensitivity to peripheral stimuli
mechanism of dextrometorphan
suppresses response of cough center but does not have analgesic or addictive potential and is less constipating than codeine
name the drug that is a mucolytic agent
NAC
n-acetylcysteine
uses of N-acetylcysteine
- management of acetaminophen overdose
- cystic fibrosis to break disulfide bonds in mucus thereby liquefying it and making it easier to cough out
H1 antagonist used for respiratory issues
FLaCCiD Fexofenadine Loratadine Cetirizine Chlorpheniramine Diphenhydramine
drugs used to treat chronic rhinitis
CCAAN
Corticosteroids: beclomethasone and flunisolide Cromolyn Alpha adrenergic agonists Antihistamines Nasal corticosteroids
antihistamines used to treat rhinitis
FLaCCCiD Fexofenadine Loratadine Cetirizine Chlorpheniramine Cyproheptadine Diphenhydramine
adverse effects of antihistamines used to tx rhinitis
1st gen - Chlorpheniramine, Cyproheptadine, and Diphenhydramine cross BBB and cause drowsiness
2nd gen - Cetirizine, Fexofenadine, and Loratadine do not produce drowsiness
mechanism of alpha adrenergic agonists
constrict dilated arterioles in nasal mucosa and reduce airway resistance
examples of alpha adrenergic agonists used in tx of rhinitis
phenylephrine (increase BP and dilate pupil)
pseudoephrine