GI Drugs III

Question 1

anti TNFalpha drug used for IBD

Answer 1

infliximab and adalimumab

Question 2

conditions that infliximab is used for

Answer 2

Crohn’s related fistulas and flare ups

rheumatoid arthritis

Question 3

adverse effect of infliximab

Answer 3

reactivation of latent tuberculosis`

Question 4

anti integrins used for IBD and adverse effect

Answer 4

natalizumab

blocks leukocyte integrins and hence can produce multifocal leukoencephalopathy

Question 5

what is irritable bowel syndrome (IBS)

Answer 5

diarrhea or constipation or alternating without structural abnormalities

Question 6

drugs used for IBS

Answer 6

Anticholinergics
5 HT3 antagonist
Opioid agonists
Chloride Channel activators

Question 7

anticholinergics used in IBS

Answer 7

Hyoscyamine
Dicyclomine
Glycopyrrolate
Methscopolamine

Question 8

5-HT3 antagonist used for IBS and adverse effects

Answer 8

Alosetron

constipation, ischemic colitis, infarction

Question 9

opioid agonist used in IBS and mechanism

Answer 9

loperamide –> acts via GI mu opioid receptor –> inhibits ACh release and decrease peristalsis

Question 10

chloride channel activator in IBS

Answer 10

lubiprostone

Question 11

used for pancreatic insufficiency and what it does

Answer 11

pancrelipase

improves digestion of dietary fat, protein, and carbs, and vit ADEK absorption

Question 12

when is pancrelipase used

Answer 12

• chronic pancreatitis, steatorrhea, pancreatectomy, CF insufficiences
• those on weight loss med Orlistat that inhibits gastric and pancreatic lipase (drug decreases absorption of vit ADEK)