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RUSVM Virology > Rhabdoviridae > Flashcards

Rhabdoviridae Flashcards

1
Q

All Lyssaviruses cause what sort of disease?

A

Rabies or Rabies-like disease

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2
Q

Bovine Ephemeral Fever Virus belongs to what Rhabdovirus genus

A

Ephemorovirus

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3
Q

Clinical sign of what Rhabdovirus

A

Novirhabdovirus - Viral haemorrhagic Septicemia Virus

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4
Q

Exposure to Viral Hemorrhagic Septicemia virus is characterized by

A

Lethargy

Spiral Swimming Pattern

Darkened body color

Pale gills

Exophthalmia

Hemorrhage at base of fins

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5
Q

Clinical sign of what Rhabdovirus

A

Vesiculovirus

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6
Q

Rhabdovirus virions are released from the host cell by

A

budding

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7
Q

Vesicular Stomatitis Virus is transmitted by

A

Biting insects

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8
Q

Viral Hemorrhagic Septicemia Virus infection occurs at what water temperatures

A

4-14C, disappears at temperature >15C

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9
Q

What histiologic finding is diagnostic of Rabies Virus infection?

A

Negri bodies

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10
Q

Rhabdovirus protein that is an inner protein that facilitates virion budding - binds N and G proteins

A

M Protein

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11
Q

Clinical features of Vesicular Stomatitis Virus in cattle and horses

A

Excessive salivation and fever

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12
Q

Incubation period of Rabies Virus

A

14-90 days, even years

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13
Q

What type of sample should be collected for rabies virus detection

A

Tissue from at least two locations in the brain

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14
Q

Characteristics of excitative (fury) phase of rabies virus infection

A

Severe agitation and aggressiveness

Animal often bites any material

Rabid dogs develop typical high barking sound

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15
Q

Internal lesions associated with Viral Hemorrhagic Septicemia Virus infection

A

Hemorrhage in several organs

Liver is mottled and variably congested

Multifocal necrosis in several organs

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16
Q

Viral Hemorrhagic Septicemia Virus causes what type of disease in fish

A

Systemic infection

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17
Q

Gold standard laboratory diagnostic test for Rabies Virus

A

Fluorescent Antibody Test (FAT)

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18
Q

Four genera that make up Family Rhabdoviridae

A

Lyssavirus

Vesiculovirus

Ephemerovirus

Novirhabdovirus

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19
Q

Clinical Features of Bovine Ephemeral Fever Virus infection

A

Seasonal

Biphasic/Polyphasic Fever

Immediate drop in milk production

Cessation of rumination

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20
Q

Pathogenesis of Rabies Virus

A
  • Virus replicates in the muscle tissue
  • Accesses the peripheral nerves through sensory or motor nerves
  • Binds to receptor for Ach at neuromuscular junction
  • Infect the CNS
  • Replicates extensively in limbic system
  • Migrates to other organs - salivary glands
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21
Q

Protein that covers the surface of Rhabdoviruses

A

G Protein (Glycoprotein)

22
Q

Rabies Virus is a member of what genus

A

Lyssavirus

23
Q

Bovine Ephemeral Fever Virus is transmitted by

A

Arthropods

24
Q

Infectious Hematopoietic Necrosis Virus belongs to what Rhabdovirus genus

A

Novirhabdovirus

25
Q

Most of rabies is caused by

A

Rabid dog bites

26
Q

Clinical feature of Vesicular Stomatitis Virus in swine

A

Lameness

27
Q

Rhabdovirus protein that makes up the major capsid compent, the viral nucleocapid

A

N Protein

28
Q

Rhabdovirus virions are (stable/unstable) in the envriontment

A

Relatively stable

29
Q

Clinical sign of what Rhabdovirus

A

Vesiculovirus

30
Q

Viral Hemorrhagic Septicemia Virus belongs to what Rhabdovirus genus

A

Novirhabdovirus

31
Q

Clinical Phases of Rabies Virus infection

A

Prodromal Phase

Excitative (Fury) Phase

Paralytic (Dumb) Phase

32
Q

RNA Viruses

Genome = Single Stranded, Linear, - Sense RNA

Enveloped

A

Rhabdoviruses

33
Q

Characteristic of paralytic (dumb) phase of rabies virus infection

A

Characterized by the inability to swallow - photophobia

Leading to typical sign of foaming saliva around the mouth

Some animals may develop paralysis beginning at the hind extremities

Complete paralysis followed by death

34
Q

Characteristics of the Prodromal Phase of Rabies Virus infection

A

Lasts 1-3 days with behavioral problems

Aggressiveness in tame animals

Daytime activities in nocturnal animals

No fear in humans in wild animals

Abnormalities in appetite

35
Q

Rhabdovirus protein that is an RNA-dependent RNA polymerase - transcription and replication of viral RNA

A

L Protein

36
Q

Characteristic microscopic lesions associated with what Rhabdovirus

A

Negri Bodies

Rabies Virus

37
Q

Rhabdovirus protein that is a co-factor of the viral polymerase

A

P Protein

38
Q

Vesicular Stomatitis Virus belongs to what Rhabdovirus genus

A

Vesiculovirus

39
Q

Vesicular Stomatitis Virus isolation method of choice

A

RT-PCR

40
Q

Rabies virus is secreted in what during fury phase

A

Saliva

41
Q

Rhabdovirus virion properties

A

RNA Virus

Single Stranded

Linear

  • sense RNA

Enveloped

Rod or Cone Shaped

42
Q

Clinical features of Vesicular Stomatitis Virus in cattle and swine

A

Vesicls on tongue, oral mucosa, teats and coronary band

43
Q

Clinical signs of infectious hematopoietic necrosis virus infection

A

Darkened body color

Lethargy

Pale gilles - anemia

Bilateral exophthalmia

Distention of abdomen - ascites

Hemorrhage at base of fin

44
Q

Rhabdovirus replication occurs in the

A

cytoplasm

45
Q

Vesicular Stomatitis Virus is (stable/unstable) in the environment

A

Stable

46
Q

Gold standard diagnostic test for Bovine Ephemeral Fever Virus

A

Virus isolation in mosquito cell culture or suckling mouse brain

47
Q

Rabies virus reservoirs in North America

A

Skunks

Raccoons

Foxes

Wolves

48
Q

Clinical sign of what Rhabdovirus

A

Novirhabdovirus - Infectious Hematopietic Necrosis Virus

49
Q

Bovine Ephemeral Fever Virus causes what disease

A

Three Day Stiff Sickness

50
Q

Infectious Hematopoietic Necrosis virus infection occurs in what water temperature

A

Juvenile fish at water temperature 8-15C

RUSVM Virology (35 decks)

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